{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:02:12Z","timestamp":1776888132855,"version":"3.51.2"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Metabolic disorder is noted for pacing\u2010induced cardiomyopathy. The benefits of His bundle pacing over right ventricular (RV) pacing in preventing pacing\u2010induced cardiomyopathy from a metabolic perspective are yet to be fully understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Method and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Three pig groups were established for this study: sham control, RV pacing (RV pacing for 6\u2009months), and His pacing (RV pacing for 6\u2009months, followed by His bundle pacing for 3\u2009months). Complete atrioventricular block was created in the last 2 groups. Left ventricular function and dyssynchrony were assessed via echocardiography, while proteins linked to metabolism, endoplasmic reticulum stress, and inflammation in left ventricular myocardium were examined. The RV pacing group had significantly more left ventricular mechanical dyssynchrony compared with the other groups. The RV pacing group exhibited triglyceride and diacylglycerol accumulation in cardiomyocytes and higher expression of binding immunoglobulin protein and tumor necrosis factor\u2010\u03b1 than the other groups. Additionally, the expression of CD36 was activated, while the expression of hormone\u2010sensitive lipase was downregulated in the RV pacing group compared with the His pacing and sham control groups. Furthermore, the expressions of GLUT4 and\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Pyruvate_dehydrogenase_kinase\">pyruvate dehydrogenase<\/jats:ext-link>\n              were higher in the RV pacing group than the sham control and His pacing groups. Notably, the abnormal fatty acid and glucose metabolic pathways in the left ventricular myocardium during RV pacing could be corrected by His bundle pacing.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">His bundle pacing can mitigate the abnormal metabolism disorders, endoplasmic reticulum stress, and inflammation induced during RV pacing and may contribute to the superiority of conduction system pacing over RV pacing in reducing heart failure hospitalization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032386","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T10:43:35Z","timestamp":1707821015000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of His Bundle Pacing on Abnormal Myocardial Fatty Acid and Glucose Metabolism Induced by Right Ventricular Pacing"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-4534","authenticated-orcid":false,"given":"Yu\u2010Sheng","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiology Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-9246","authenticated-orcid":false,"given":"Huang\u2010Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-6134","authenticated-orcid":false,"given":"Wei\u2010Chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Chi Mei Medical Center Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6538-7380","authenticated-orcid":false,"given":"Wan\u2010Chun","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-7785","authenticated-orcid":false,"given":"Shun\u2010Fu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research and Development Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung 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