{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:34:32Z","timestamp":1772710472530,"version":"3.50.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Pretricuspid shunts have been associated with poorer survival rates in patients with Eisenmenger syndrome compared with postricuspid shunts and complex lesions. However, the risk stratification for persistent pulmonary hypertension (PH) in this population remains uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively enrolled 103 patients with pretricuspid shunts with high total pulmonary resistance &gt;4.5 Wood units (estimated pulmonary vascular resistance \u22653 Wood units). During a mean\u00b1SD follow\u2010up of 20.95\u00b124.84\u2009months, 32 patients developed postoperative persistent PH after shunt correction. We identified 3 significant predictors of postoperative persistent PH, including mean pulmonary artery pressure after inhaled oxygen \u226540.5\u2009mm\u2009Hg (odds ratio [OR], 7.78 [95% CI, 2.02\u201330.03];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), total pulmonary resistance after inhaled oxygen \u22656.5 Wood units (estimated pulmonary vascular resistance \u22655 Wood units; OR, 12.23 [95% CI, 2.12\u201370.46];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), and artery oxygen saturation at rest &lt;95% (OR, 3.34 [95% CI, 1.07\u201310.44];\n              <jats:italic>P<\/jats:italic>\n              =0.04). We established the prediction model with the C\u2010statistics of 0.85 (95% CI, 0.77\u20130.93;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), and the C\u2010statistic was 0.83 (95% CI, 0.80\u20130.86) after bootstrapping 10\u2009000 times with a good performance of the nomogram calibration curve for predicting persistent PH.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study presents a multivariable risk stratification model for persistent PH after shunt correction in adults with pretricuspid shunts. This model, based on 3 hemodynamic predictors after inhaled oxygen, may assist in identifying individuals at higher risk of persistent PH after shunt correction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032412","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T11:08:48Z","timestamp":1713524928000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Development and Validation of a Nomogram of Persistent Pulmonary Hypertension in Adult Pretricuspid Shunts After Correction"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-0571","authenticated-orcid":false,"given":"Zeming","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Department of 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