{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:44:02Z","timestamp":1793421842659,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Symptomatic limitations in apical hypertrophic cardiomyopathy may occur because of diastolic dysfunction with resultant elevated left ventricular filling pressures, cardiac output limitation to exercise, pulmonary hypertension (PH), valvular abnormalities, and\/or arrhythmias. In this study, the authors aimed to describe invasive cardiac hemodynamics in a cohort of patients with apical hypertrophic cardiomyopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients presenting to a comprehensive hypertrophic cardiomyopathy center with apical hypertrophic cardiomyopathy were identified (n=542) and those who underwent invasive hemodynamic catheterization (n=47) were included in the study. Of these, 10 were excluded due to postmyectomy status or incomplete hemodynamic data. The mean age was 56\u00b118\u2009years, 16 (43%) were women, and ejection fraction was preserved (\u226550%) in 32 (91%) patients. The most common indication for catheterization was dyspnea (48%) followed by suspected PH (13%), and preheart transplant evaluation (10%). Elevated left ventricular filling pressures at rest or exercise were present in 32 (86%) patients. PH was present in 30 (81%) patients, with 6 (20%) also having right\u2010sided heart failure. Cardiac index was available in 25 (86%) patients with elevated resting filling pressures. Of these, 19 (76%) had reduced cardiac index and all 6 with right\u2010sided heart failure had reduced cardiac index. Resting hemodynamics were normal in 8 of 37 (22%) patients, with 5 during exercise; 3 of 5 (60%) patients had exercise\u2010induced elevation in left ventricular filling pressures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with apical hypertrophic cardiomyopathy undergoing invasive hemodynamic cardiac catheterization, 86% had elevated left ventricular filling pressures at rest or with exercise, 81% had PH, and 20% of those with PH had concomitant right\u2010sided heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032520","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T11:28:59Z","timestamp":1714476539000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Invasive Cardiac Hemodynamics in Apical Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"13","author":[{"given":"Awais A.","family":"Malik","sequence":"first","affiliation":[{"name":"Mayo Clinic, Department of Cardiovascular Medicine Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-6493","authenticated-orcid":false,"given":"Ushasi","family":"Saraswati","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Cardiovascular Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8474","authenticated-orcid":false,"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Cardiovascular Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-4357","authenticated-orcid":false,"given":"Megan","family":"Covington","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Cardiovascular Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-0647","authenticated-orcid":false,"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Cardiovascular Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-672X","authenticated-orcid":false,"given":"Alex T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Quantitative Health Sciences Rochester MN 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Bull Eur Physiopathol Respir. 1979;15:935\u2013949.","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.37.6.922"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000938"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26472"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25856"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.032520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:13:24Z","timestamp":1715602404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.032520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,5,7]]}},"alternative-id":["10.1161\/JAHA.123.032520"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.032520","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]},"assertion":[{"value":"2023-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e032520"}}