{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:06:24Z","timestamp":1792551984943,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with osteoporosis demonstrate increased vascular calcification but the effect of osteoporosis treatments on vascular calcification remains unclear. The present study aimed to examine whether coronary or aortic calcification are influenced by denosumab and alendronic acid treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a double\u2010blind randomized controlled SALTIRE2 (Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis) trial, patients with aortic stenosis were randomized 2:1:2:1 to denosumab, placebo injection, alendronic acid, or placebo capsule. Participants underwent serial imaging with computed tomography and 18F\u2010sodium fluoride positron emission tomography for the assessment of vascular calcium burden and calcification activity, respectively. We report the prespecified secondary analyses of 24\u2010month change in coronary calcium score, and 12\u2010month changes in thoracic aorta calcium score, coronary and aortic 18F\u2010sodium fluoride activity. One hundred fifty patients with aortic stenosis (72\u00b18\u2009years; 21% female) were randomized to denosumab (n=49), alendronic acid (n=51), and placebo (injection n=25, capsule n=25). There were no differences in change in coronary calcium scores between placebo (16 [\u221264 to 148] Agatston units) and either denosumab (94 [0\u2013212] Agatston units,\n              <jats:italic>P<\/jats:italic>\n              =0.24) or alendronic acid (34 [\u221262 to 134],\n              <jats:italic>P<\/jats:italic>\n              =0.99). There were no differences in change in thoracic aorta calcium scores between placebo (132 [22\u2013512] Agatston units) and either denosumab (118 [11\u2013340],\n              <jats:italic>P<\/jats:italic>\n              =0.75) or alendronic acid (116 [26\u2013498] Agatston units,\n              <jats:italic>P<\/jats:italic>\n              =0.62). There were no differences in changes in coronary or aortic 18F\u2010sodium fluoride activity between treatment groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Neither alendronic acid nor denosumab are associated with changes in the activity or progression of coronary or aortic calcification. Osteoporosis treatments do not appear to have major impact on vascular calcification of atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02132026.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032571","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:14:24Z","timestamp":1725880464000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Denosumab or Alendronate on Vascular Calcification: Secondary Analysis of SALTIRE2 Randomized Controlled Trial"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-5191","authenticated-orcid":false,"given":"Jolien","family":"Geers","sequence":"first","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"},{"name":"Department of Cardiology Universitair Ziekenhuis Brussel (UZ Brussel) Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-4906","authenticated-orcid":false,"given":"Rong","family":"Bing","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania A.","family":"Pawade","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhairi K.","family":"Doris","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Daghem","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-8391","authenticated-orcid":false,"given":"Alexander J.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"},{"name":"Department of Child Health University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-9468","authenticated-orcid":false,"given":"Audrey C.","family":"White","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-0392","authenticated-orcid":false,"given":"Laura","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Edinburgh Clinical Trials Unit University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Evans","sequence":"additional","affiliation":[{"name":"Edinburgh Clinical Research Facility University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-6359","authenticated-orcid":false,"given":"Jacek","family":"Kwieci\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Angiology Institute of Cardiology Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-2428","authenticated-orcid":false,"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"},{"name":"Edinburgh Imaging University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-5071","authenticated-orcid":false,"given":"Edwin J. 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