{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:54:19Z","timestamp":1753887259141,"version":"3.41.2"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data on the incidence of type 2 non\u2013ST\u2010segment\u2013elevation myocardial infarction (T2MI) in hospitalized patients with COVID\u201019 has been limited to single\u2010center studies. Given that certain characteristics, such as obesity and type 2 diabetes, have been associated with higher mortality in COVID\u201019 infections, we aimed to define the incidence of T2MI in a national cohort and identify pre\u2010hospital patient characteristics associated with T2MI in hospitalized patients with COVID\u201019.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the national American Heart Association COVID\u201019 Cardiovascular Disease Quality Improvement Registry, we performed a retrospective 4:1 matched (age, sex, race, and body mass index) analysis of controls versus cases with T2MI. We performed (1) conditional multivariable logistic regression to identify predictive pre\u2010hospital patient characteristics of T2MI for patients hospitalized with COVID\u201019 and (2) stratified proportional hazards regression to investigate the association of T2MI with morbidity and mortality. From January 2020 through May 2021, there were 709 (2.2%) out of 32 015 patients with T2MI. Five hundred seventy\u2010nine cases with T2MI were matched to 2171 controls (mean age 70; 43% female). Known coronary artery disease, heart failure, chronic kidney disease, hypertension, payor source, and presenting heart rate were associated with higher odds of T2MI. Anti\u2010hyperglycemic medication and anti\u2010coagulation use before admission were associated with lower odds of T2MI. Those with T2MI had higher morbidity and mortality (hazard ratio, 1.40 [95% CI, 1.13\u20131.74];\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In hospitalized patients with COVID\u201019, those with a T2MI compared with those without had higher morbidity and mortality. Outpatient anti\u2010hyperglycemic and anti\u2010coagulation use were the only pre\u2010admission factors associated with reduced odds of T2MI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032572","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:34:30Z","timestamp":1715337270000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, Predictors, and Outcomes of Type 2 NSTEMI in Hospitalized Patients With COVID\u201019"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-4547","authenticated-orcid":false,"given":"Sahishnu","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Visotcky","sequence":"additional","affiliation":[{"name":"Division of 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