{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:55:56Z","timestamp":1792274156673,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are few data on sex differences in the association between schizophrenia and the development of cardiovascular disease (CVD). We sought to clarify the relationship of schizophrenia with the risk of developing CVDs and to explore the potential modification effect of sex differences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a retrospective analysis using the JMDC Claims Database between 2005 and 2022. The study population included 4\u2009124\u2009508 individuals aged 18 to 75\u2009years without a history of CVD or renal replacement therapy. The primary end point is defined as a composite end point that includes myocardial infarction, angina pectoris, stroke, heart failure, atrial fibrillation, and pulmonary thromboembolism. During a mean follow\u2010up of 1288\u00b11001\u2009days, we observed 182\u2009158 composite end points. We found a significant relationship of schizophrenia with a greater risk of developing composite CVD events in both men and women, with a stronger association observed in women. The hazard ratio for the composite end point was 1.63 (95% CI, 1.52\u20131.74) in women and 1.42 (95% CI, 1.33\u20131.52) in men after multivariable adjustment (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.0049). This sex\u2010specific difference in the association between schizophrenia and incident CVD was consistent for angina pectoris, heart failure, and atrial fibrillation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our analysis using a large\u2010scale epidemiologic cohort demonstrated that the association between schizophrenia and subsequent CVD events was more pronounced in women than in men, suggesting the clinical importance of addressing schizophrenia and tailoring the CVD prevention strategy based on sex\u2010specific factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032625","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T15:47:49Z","timestamp":1709048869000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Sex Differences in the Relationship Between Schizophrenia and the Development of Cardiovascular Disease"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3003-2751","authenticated-orcid":false,"given":"Jin","family":"Komuro","sequence":"first","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"},{"name":"Department of Cardiology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"},{"name":"The Department of Advanced Cardiology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9406-4691","authenticated-orcid":false,"given":"Yuta","family":"Suzuki","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"},{"name":"Center for Outcomes Research and Economic Evaluation for Health National Institute of Public Health Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-3388","authenticated-orcid":false,"given":"Akira","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Prevention of Diabetes and Lifestyle\u2010Related Diseases, Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Fujiu","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo 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