{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:15:01Z","timestamp":1788419701923,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Whether cardiovascular dysfunction is associated with preeclampsia in women without fetal growth restriction (FGR) is unclear. Our objective was to investigate associations between third\u2010trimester cardiac output (CO) and systemic vascular resistance and risk of hypertensive disorders of pregnancy in women with and without FGR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A case\u2013cohort study in 906 pregnant women in Denmark with repeated third\u2010trimester cardiac function assessments was performed using the Ultrasound Cardiac Output Monitor 1A. Using Cox regression, we compared rates of hypertensive disorders of pregnancy in women with low, normal, and high CO and normal and high systemic vascular resistance, by FGR status and gestational age, and evaluated associations between a third\u2010trimester drop in CO or increase in systemic vascular resistance and preeclampsia risk in women without FGR. The analysis included 249 women with preeclampsia (42 with FGR) and 119 women with gestational hypertension. Low CO was strongly associated with preeclampsia at &lt;37\u2009weeks (women with FGR: hazard ratio [HR], 5.25 [95% CI, 1.26\u201321.9]; women without FGR: HR, 2.19 [95% CI, 1.07\u20134.48]). Our results also suggested an association between low CO and preeclampsia at \u226537\u2009weeks among women without FGR (HR, 1.31 [95% CI, 0.84\u20132.03]), and between a third\u2010trimester drop in CO &gt;75th percentile and preeclampsia in women without FGR (odds ratio, 1.91 [95% CI, 0.84\u20134.36]). High systemic vascular resistance was strongly associated with increased rates of all forms of hypertensive disorders of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Low CO is associated with preeclampsia risk in women with and without FGR, particularly before 37\u2009weeks. Repeated measurements of third\u2010trimester cardiovascular function might identify women without FGR for monitoring for preeclampsia, but this result needs to be confirmed in other studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032673","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T07:14:16Z","timestamp":1728630856000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Third\u2010Trimester Cardiovascular Function and Risk of Hypertensive Disorders of Pregnancy"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-8905","authenticated-orcid":false,"given":"Frederikke","family":"Lihme","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-2982","authenticated-orcid":false,"given":"Saima","family":"Basit","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-1225","authenticated-orcid":false,"given":"Lisa G.","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"},{"name":"Department of Obstetrics Copenhagen University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria O.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin H.","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-9792","authenticated-orcid":false,"given":"Jacob A.","family":"Lykke","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Copenhagen University Hospital Herlev Denmark"},{"name":"Department of Gynaecology and Obstetrics Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Thorsen\u2010Meyer","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-3388","authenticated-orcid":false,"given":"Kasper","family":"Pihl","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6785","authenticated-orcid":false,"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[{"name":"Danish Cancer Institute Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Genetics Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-2247","authenticated-orcid":false,"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"},{"name":"Danish Cancer Institute Cancer Epidemiology and Surveillance Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-9985","authenticated-orcid":false,"given":"Heather A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11191"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2022.105669"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23392"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.04.007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117358"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.02.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.052"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0766-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16269"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.029"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18835"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199912000-00014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12917"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.04.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15915"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu162"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2005.00722.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000086"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001940"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17667s"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp107"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90901-0"},{"key":"e_1_3_2_29_2","first-page":"1061","article-title":"Maternal hemodynamics in normal and preeclamptic pregnancies: a longitudinal study","volume":"76","author":"Easterling TR","year":"1990","unstructured":"Easterling TR, Benedetti TJ, Schmucker BC, Millard SP. Maternal hemodynamics in normal and preeclamptic pregnancies: a longitudinal study. Obstet Gynecol. 1990;76:1061\u20131069.","journal-title":"Obstet Gynecol"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2012.697951"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.6.1072"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90357-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1873269"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.033"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3901"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20612"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17300"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17504"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.032673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T23:11:35Z","timestamp":1729033895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.032673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":37,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,10,15]]}},"alternative-id":["10.1161\/JAHA.123.032673"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.032673","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]},"assertion":[{"value":"2023-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e032673"}}