{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:05:43Z","timestamp":1787907943388,"version":"build-2784847793"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remain unknown. The study objective was to examine the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Apparently healthy adult participants (n=280) were randomized to an 8\u2010minute anger recall task, a depressed mood recall task, an anxiety recall task, or an emotionally neutral condition. Pre\u2212\/post\u2010assessments of endothelial health including endothelium\u2010dependent vasodilation (reactive hyperemia index), circulating endothelial cell\u2010derived microparticles (CD62E+, CD31+\/CD42\u2212, and CD31+\/Annexin V+) and circulating bone marrow\u2010derived endothelial progenitor cells (CD34+\/CD133+\/kinase insert domain receptor+ endothelial progenitor cells and CD34+\/kinase insert domain receptor+ endothelial progenitor cells) were measured. There was a group\u00d7time interaction for the anger versus neutral condition on the change in reactive hyperemia index score from baseline to 40 minutes (\n                      <jats:italic>P<\/jats:italic>\n                      =0.007) with a mean\u00b1SD change in reactive hyperemia index score of 0.20\u00b10.67 and 0.50\u00b10.60 in the anger and neutral conditions, respectively. For the change in reactive hyperemia index score, the anxiety versus neutral condition group by time interaction approached but did not reach statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      =0.054), and the sadness versus neutral condition group by time interaction was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      =0.160). There were no consistent statistically significant group\u00d7time interactions for the anger, anxiety, and sadness versus neutral condition on endothelial cell\u2010derived microparticles and endothelial progenitor cells from baseline to 40\u2009minutes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this randomized controlled experimental study, a brief provocation of anger adversely affected endothelial cell health by impairing endothelium\u2010dependent vasodilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032698","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T05:30:28Z","timestamp":1714541428000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8834","authenticated-orcid":false,"given":"Daichi","family":"Shimbo","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"St. John\u2019s University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-397X","authenticated-orcid":false,"given":"Matthew","family":"McGoldrick","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center New York NY 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