{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:27:49Z","timestamp":1793366869719,"version":"4.5.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Autonomic function can be measured noninvasively using heart rate variability (HRV), which indexes overall sympathovagal balance. Deceleration capacity (DC) of heart rate is a more specific metric of vagal modulation. Higher values of these measures have been associated with reduced mortality risk primarily in patients with cardiovascular disease, but their significance in community samples is less clear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This prospective twin study followed 501 members from the VET (Vietnam Era Twin) registry. At baseline, frequency domain HRV and DC were measured from 24\u2010hour Holter ECGs. During an average 12\u2010year follow\u2010up, all\u2010cause death was assessed via the National Death Index. Multivariable Cox frailty models with random effect for twin pair were used to examine the hazard ratios of death per 1\u2010SD increase in log\u2010transformed autonomic metrics. Both in the overall sample and comparing twins within pairs, higher values of low\u2010frequency HRV and DC were significantly associated with lower hazards of all\u2010cause death. In within\u2010pair analysis, after adjusting for baseline factors, there was a 22% and 27% lower hazard of death per 1\u2010SD increment in low\u2010frequency HRV and DC, respectively. Higher low\u2010frequency HRV and DC, measured during both daytime and nighttime, were associated with decreased hazard of death, but daytime measures showed numerically stronger associations. Results did not substantially vary by zygosity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Autonomic inflexibility, and especially vagal withdrawal, are important mechanistic pathways of general mortality risk, independent of familial and genetic factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032740","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T12:08:30Z","timestamp":1711541310000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study"],"prefix":"10.1161","volume":"13","author":[{"given":"Minxuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University Atlanta 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