{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:39:16Z","timestamp":1793813956520,"version":"4.6.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left atrial reservoir strain (LARS) is a novel imaging biomarker of left ventricular diastolic dysfunction. This study aimed to examine the prognostic implications of LARS in patients with bicuspid aortic valve and significant (moderate\u2010severe to severe) aortic regurgitation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 220 patients with bicuspid aortic valve and significant aortic regurgitation were prospectively enrolled in our study. LARS and left ventricular global longitudinal strain were derived from speckle\u2010tracking echocardiography. The end point was a composite of all\u2010cause mortality, heart failure hospitalization, and aortic valve repair or replacement. The threshold value of LARS &lt;24% was used to identify impaired left atrial mechanics based on prior results. During a median follow\u2010up of 364 (interquartile range, 294\u2013752) days, 46 patients (20.9%) reached the composite end points. On multivariable Cox analysis, impaired LARS (adjusted hazard ratio, 2.08 [95% CI, 1.05\u20134.11];\n              <jats:italic>P<\/jats:italic>\n              =0.036) was a statistically significant predictor of composite end points after adjustment for other statistically significant predictors. Finally, adding impaired LARS to other statistically significant predictors (New York Heart Association functional class and left ventricular global longitudinal strain) significantly improved the global \u03c7\n              <jats:sup>2<\/jats:sup>\n              (from 32.19 to 36.56;\n              <jats:italic>P<\/jats:italic>\n              =0.037) and reclassification (continuous net reclassification index=0.55;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) of the prediction model.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with bicuspid aortic valve and significant aortic regurgitation, the impairment of LARS is a strong independent prognostic predictor and confers incremental prognostic utility over clinical and other echocardiographic parameters. These findings suggest that LARS could be considered in risk stratification for such populations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032770","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T11:02:13Z","timestamp":1710759733000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic Implications of Left Atrial Strain in Bicuspid Aortic Valve With Chronic Aortic Regurgitation"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-5013","authenticated-orcid":false,"given":"YuTing","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province Wuhan Hubei Province China"},{"name":"Hubei Province Key Laboratory of 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