{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:40:05Z","timestamp":1783456805041,"version":"3.55.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The prognosis of high or markedly low diastolic blood pressure (DBP) with normalized on\u2010treatment systolic blood pressure on major adverse cardiovascular events (MACEs) is uncertain. This study examined whether treated isolated diastolic hypertension (IDH) and treated isolated low DBP (ILDBP) were associated with MACEs in patients with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 7582 patients with on\u2010treatment systolic blood pressure &lt;130\u2009mm\u2009Hg from SPRINT (Systolic Blood Pressure Intervention Trial) were categorized on the basis of average DBP: &lt;60\u2009mm\u2009Hg (n=1031; treated ILDBP), 60 to 79\u2009mm\u2009Hg (n=5432), \u226580\u2009mm\u2009Hg (n=1119; treated IDH). MACE risk was estimated using Cox proportional\u2010hazards models. Among the SPRINT participants, median age was 67.0\u2009years and 64.9% were men. Over a median follow\u2010up of 3.4\u2009years, 512 patients developed a MACE. The incidence of MACEs was 3.9 cases per 100 person\u2010years for treated ILDBP, 1.9 cases for DBP 60 to 79\u2009mm\u2009Hg, and 1.8 cases for treated IDH. Comparing with DBP 60 to 79\u2009mm\u2009Hg, treated ILDBP was associated with an 1.32\u2010fold MACE risk (hazard ratio [HR], 1.32, 95% CI, 1.05\u20131.66), whereas treated IDH was not (HR, 1.18 [95% CI, 0.87\u20131.59]). There was no effect modification by age, sex, atherosclerotic cardiovascular disease risk, or cardiovascular disease history (all\n                      <jats:italic>P<\/jats:italic>\n                      values for interaction &gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this secondary analysis of SPRINT, among treated patients with normalized systolic blood pressure, excessively low DBP was associated with an increased MACE risk, while treated IDH was not. Further research is required for treated ILDBP management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032771","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T07:03:03Z","timestamp":1712905383000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure"],"prefix":"10.1161","volume":"13","author":[{"given":"Wei\u2010Lun","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Faculty Development Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Taipei Veterans General Hospital Taipei 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