{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:30:44Z","timestamp":1778110244050,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter edge\u2010to\u2010edge repair (TEER) of mitral regurgitation is less invasive than surgery but has greater 5\u2010year mortality and reintervention risks, and leads to smaller improvements in physical functioning. The study objective was to quantify patient preferences for risk\u2013benefit trade\u2010offs associated with TEER and surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A discrete choice experiment survey was administered to patients with mitral regurgitation. Attributes included procedure type; 30\u2010day mortality risk; 5\u2010year mortality risk and physical functioning for 5\u2009years; number of hospitalizations in the next 5\u2009years; and risk of additional surgery in the next 5\u2009years. A mixed\u2010logit regression model was fit to estimate preference weights. Two hundred one individuals completed the survey: 63% were female and mean age was 74\u2009years. On average, respondents preferred TEER over surgery. To undergo a less invasive procedure (ie, TEER), respondents would accept up to a 13.3% (95% CI, 8.7%\u201318.5%) increase in reintervention risk above a baseline of 10%, 4.6 (95% CI, 3.1\u20136.2) more hospitalizations above a baseline of 1, a 10.7% (95% CI, 6.5%\u201314.5%) increase in 5\u2010year mortality risk above a baseline of 20%, or more limited physical functioning representing nearly 1 New York Heart Association class (0.7 [95% CI, 0.4\u20131.1]) over 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients in general preferred TEER over surgery. When holding constant all other factors, a functional improvement from New York Heart Association class III to class I maintained over 5\u2009years would be needed, on average, for patients to prefer surgery over TEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032807","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T22:09:46Z","timestamp":1710281386000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Patient Risk\u2013Benefit Preferences for Transcatheter Versus Surgical Mitral Valve Repair"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-431X","authenticated-orcid":false,"given":"Anna","family":"Hung","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"},{"name":"Center of Innovation to Accelerate Discovery and Practice Transformation Durham Veterans Affairs Health Care System Durham NC USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-6578","authenticated-orcid":false,"given":"Jui\u2010Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Wallace","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany A.","family":"Zwischenberger","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular and Thoracic Surgery, Department of Surgery Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-2957","authenticated-orcid":false,"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"},{"name":"Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-1719","authenticated-orcid":false,"given":"Robert J.","family":"Mentz","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"},{"name":"Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Thoma","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Goates","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lewis","sequence":"additional","affiliation":[{"name":"Heart Valve Voice US Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Strong","sequence":"additional","affiliation":[{"name":"Heart Valve Voice US Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby D.","family":"Reed","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2133"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_3_2_7_2","unstructured":"MitraClip REPAIR MR Study . 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