{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:46:38Z","timestamp":1781909198721,"version":"3.54.5"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The influence of burden of atherosclerosis in the brain supplying arteries on mortality in patients with acute ischemic stroke or transient ischemic attack is poorly known. We assessed whether total burden of atherosclerosis within cervicocerebral arteries is associated with long\u2010term mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 406 patients (median age, 71.8\u2009years; 57.9% male) with acute ischemic stroke or transient ischemic attack were included and their cervicocerebral arteries imaged with computed tomography angiography. The presence of atherosclerotic findings was scored for 25 artery segments and points were summed as a Cervicocerebral Atherosclerosis Burden (CAB) score, analyzed as quartiles. Data on all\u2010cause mortality came from Statistics Finland. After a median follow\u2010up of 7.3\u2009years, 147 (33.5%) patients had died. Compared with surviving patients, those who died had a higher median CAB score (5, interquartile range 2\u201310 versus 11, 7\u201316;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Cumulative mortality increased from 8.9% (95% CI, 7.0\u201310.8) in the lowest to 61.4% (95% CI, 55.4\u201367.4) in the highest quartile of CAB score. Adjusted for demographics, cardiovascular risk factors, secondary preventive medication, and admission National Institute of Health Stroke Scale score, every CAB score point increased probability of death by 3%. Analyzed in quartiles, the highest CAB quartile was associated with a 2.5\u2010fold likelihood of all\u2010cause mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The main findings of our study were the increasing mortality with the total burden of computed tomography angiography\u2010defined atherosclerosis in the brain supplying arteries after ischemic stroke or transient ischemic attack and that the CAB score\u2014integrating this pathology\u2014independently increased all\u2010cause mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032938","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:47:59Z","timestamp":1717678079000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Cervicocerebral Atherosclerosis Burden Increases Long\u2010Term Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-1807","authenticated-orcid":false,"given":"Kati","family":"Lainelehto","sequence":"first","affiliation":[{"name":"Department of Neurology Kanta H\u00e4me Central Hospital H\u00e4meenlinna Finland"},{"name":"Emergency Department Acuta Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-3095","authenticated-orcid":false,"given":"Juha\u2010Pekka","family":"Pienim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Radiology Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9265-674X","authenticated-orcid":false,"given":"Sirpa","family":"Savilahti","sequence":"additional","affiliation":[{"name":"Department of Radiology Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1372-430X","authenticated-orcid":false,"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-0269","authenticated-orcid":false,"given":"Heikki","family":"Numminen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-6104","authenticated-orcid":false,"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Hospital and University of Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000317107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00067-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.5.699"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020913"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008562"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225906"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.433"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(00)00300-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0431-7"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.032938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:17:18Z","timestamp":1730816238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.032938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":11,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7,2]]}},"alternative-id":["10.1161\/JAHA.123.032938"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.032938","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"assertion":[{"value":"2023-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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