{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:11:01Z","timestamp":1793394661440,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Systemic chronic inflammation plays a role in the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction\u2010associated fatty liver disease. This study aimed to investigate whether serum hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein) levels were associated with the future risk of heart failure (HF) hospitalization in patients with metabolic dysfunction\u2010associated fatty liver disease and a normal left ventricular ejection fraction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The study enrolled consecutive individuals with metabolic dysfunction\u2010associated fatty liver disease and normal left ventricular ejection fraction who underwent coronary angiography for suspected coronary heart disease. The study population was subdivided into non\u2010HF, pre\u2010HFpEF, and HFpEF groups at baseline. The study outcome was time to the first hospitalization for HF. In 10\u2009019 middle\u2010aged individuals (mean age, 63.3\u00b110.6\u2009years; 38.5% women), the prevalence rates of HFpEF and pre\u2010HFpEF were 34.2% and 34.5%, with a median serum hs\u2010CRP level of 4.5\u2009mg\/L (interquartile range, 1.9\u201310\u2009mg\/L) and 5.0\u2009mg\/L (interquartile range, 2.1\u201310.1\u2009mg\/L), respectively. Serum hs\u2010CRP levels were significantly higher in the pre\u2010HFpEF and HFpEF groups than in the non\u2010HF group. HF hospitalizations occurred in 1942 (19.4%) patients over a median of 3.2\u2009years, with rates of 3.7% in non\u2010HF, 20.8% in pre\u2010HFpEF, and 32.1% in HFpEF, respectively. Cox regression analyses showed that patients in the highest hs\u2010CRP quartile had a \u22484.5\u2010fold increased risk of being hospitalized for HF compared with those in the lowest hs\u2010CRP quartile (adjusted\u2010hazard ratio, 4.42 [95% CI, 3.72\u20135.25]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">There was a high prevalence of baseline pre\u2010HFpEF and HFpEF in patients with metabolic dysfunction\u2010associated fatty liver disease and suspected coronary heart disease. There was an increased risk of HF hospitalization in those with elevated hs\u2010CRP levels.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032997","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T11:39:52Z","timestamp":1705664392000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["High\u2010Sensitivity C\u2010Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction\u2010Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0818","authenticated-orcid":false,"given":"Xiao\u2010Dong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Heart Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-5004","authenticated-orcid":false,"given":"Qin\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Care Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Institute of Aging, Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona Italy"},{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore\u2013Don Calabria Hospital Negrar di Valpolicella (VR) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton, and University of Southampton, Southampton General Hospital Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-3287","authenticated-orcid":false,"given":"Michael D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine Wake Forest University School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tian","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Xiao","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-2145","authenticated-orcid":false,"given":"Ki\u2010Chul","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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