{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:41Z","timestamp":1792803581290,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Marfan syndrome (MFS) is a genetic disorder affecting the vascular and musculoskeletal systems. Limited knowledge exists regarding the exercise benefits for this population. This study aimed to explore the impact of a structured exercise program on the quality of life (QoL) and physical capabilities of patients with MFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">This was a randomized, controlled, parallel\u2010group trial. Patients with MFS were randomized in a 1:1 ratio to either a training group or a control group. The trial included a 3\u2010month online supervised training program. Seventy patients with MFS were compared with healthy subjects. They were randomized into a training group (MFS\u2010T) and a control group (MFS\u2010C). The training consisted of 2 supervised online sessions weekly for 3\u2009months. The primary outcome was QoL, assessed using the Medical Outcomes Study Short\u2010Form 36 questionnaire. Baseline QoL in all dimensions was lower in patients with MFS. Their peak oxygen uptake was 25% lower, and muscle elasticity was diminished compared with healthy subjects. Postintervention, significant improvements were observed in the MFS\u2010T group relative to the MFS\u2010C group: QoL (+20.2\u00b114.3 versus +0.7\u00b10.5), peak oxygen uptake (+34% versus +14%), muscle elasticity index (11.5\u00b18.2 versus +1.2\u00b11.7), reduced blood pressures during isometric squats (systolic \u221219\u00b130 versus 0\u00b16; diastolic \u221227\u00b139 versus +2\u00b115), and reduced pulse wave velocity at rest (\u22121.20\u00b11.89 versus \u22120.40\u00b11.61) and postexercise (\u22120.42\u00b10.45 versus +0.08\u00b10.48). The aortic diameter remained stable in both groups (MFS\u2010T\u22120.19\u00b11.1 versus MFS\u2010C+0.11\u00b10.78). After training, QoL remained lower in MFS\u2010T than in healthy subjects, but peak oxygen uptake, pulse wave velocity at rest, and postexercise were similar to those of healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The 3\u2010month online training program significantly enhanced QoL and cardiovascular\/muscular metrics in patients with MFS without affecting aortic root diameter, suggesting its potential as part of a management strategy for MFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04553094.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033024","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T05:28:57Z","timestamp":1726637337000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Online Personal Training in Patients With Marfan Syndrome: A Randomized Controlled Study of Its Impact on Quality of Life and Physical Capacity"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-9818","authenticated-orcid":false,"given":"Steeve","family":"Jouini","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, URP 3625\u2010Institut des Sciences du Sport Sant\u00e9 de Paris (I3SP) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-0559","authenticated-orcid":false,"given":"Olivier","family":"Milleron","sequence":"additional","affiliation":[{"name":"Centre national de r\u00e9f\u00e9rence pour le syndrome de Marfan et pathologies apparent\u00e9s Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Bichat Paris France"},{"name":"Service de Cardiologie, Centre National de R\u00e9f\u00e9rence Pour le Syndrome de Marfan et Apparent\u00e9s AP\u2010HP, H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2995-804X","authenticated-orcid":false,"given":"Ludivine","family":"Eliahou","sequence":"additional","affiliation":[{"name":"Centre national de r\u00e9f\u00e9rence pour le syndrome de Marfan et pathologies apparent\u00e9s Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Bichat Paris France"},{"name":"Service de Cardiologie, Centre National de R\u00e9f\u00e9rence Pour le Syndrome de Marfan et Apparent\u00e9s AP\u2010HP, H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-2076","authenticated-orcid":false,"given":"Guillaume","family":"Jondeau","sequence":"additional","affiliation":[{"name":"Centre national de r\u00e9f\u00e9rence pour le syndrome de Marfan et pathologies apparent\u00e9s Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Bichat Paris France"},{"name":"Service de Cardiologie, Centre National de R\u00e9f\u00e9rence Pour le Syndrome de Marfan et Apparent\u00e9s AP\u2010HP, H\u00f4pital Bichat Paris France"},{"name":"Laboratory for Vascular Translational Science Universit\u00e9 Paris Cit\u00e9, INSERM U1148, H\u00f4pital Bichat\u2010Claude\u2010Bernard Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-1880","authenticated-orcid":false,"given":"Damien","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, URP 3625\u2010Institut des Sciences du Sport Sant\u00e9 de Paris (I3SP) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124112"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq127"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.5.633"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501970306095"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600405.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00298-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001800.pub3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa605"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw106"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)67789-6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006438"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00132.2017"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2021.01080"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0679-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306440"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amcp.2016.01.010"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(02)04711-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00612"},{"key":"e_1_3_2_21_2","first-page":"109","article-title":"A new approach to monitoring exercise training","volume":"15","author":"Foster C","year":"2001","unstructured":"Foster C, Florhaug JA, Franklin J, Gottschall L, Hrovatin LA, Parker S, Doleshal P, Dodge C. A new approach to monitoring exercise training. J Strength Cond Res. 2001;15:109\u2013115.","journal-title":"J Strength Cond Res"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ea4c1c"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01633-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1026"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.10.003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel450"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198502060-00002"},{"key":"e_1_3_2_28_2","first-page":"89","article-title":"Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization","volume":"68","author":"Davis EC","year":"1993","unstructured":"Davis EC. Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization. Lab Investig. 1993;68:89\u201399.","journal-title":"Lab Investig"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706585"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.033024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T05:46:27Z","timestamp":1728452787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.033024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":28,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1161\/JAHA.123.033024"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.033024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.16.23289922","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2023-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e033024"}}