{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:07:31Z","timestamp":1785539251060,"version":"3.56.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Blood pressure (BP) trajectories from young adulthood through middle age are associated with cardiovascular risk. We examined the associations of hypertension risk factors with BP trajectories among a large diverse sample.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed data from young adults, aged 18 to 39\u2009years, with untreated BP &lt;140\/90\u2009mm Hg at baseline from Kaiser Permanente Southern California (N=355\u2009324). We used latent growth curve models to identify 10\u2010year BP trajectories and to assess the associations between characteristics in young adulthood and BP trajectories. We identified the following 5 distinct systolic BP trajectories, which appeared to be determined mainly by the baseline BP with progressively higher BP at each year: group 1 (lowest BP trajectory, 7.9%), group 2 (26.5%), group 3 (33.0%), group 4 (25.4%), and group 5 (highest BP trajectory, 7.3%). Older age (adjusted odds ratio for 30\u201339 versus 18\u201329\u2009years, 1.23 [95% CI, 1.18\u20131.28]), male sex (13.38 [95% CI, 12.80\u201313.99]), obesity (body mass index \u226530 versus 18.5\u201324.9 kg\/m\n              <jats:sup>2<\/jats:sup>\n              , 14.81 [95% CI, 14.03\u201315.64]), overweight (body mass index 25\u201329.9 versus 18.5\u201324.9 kg\/m\n              <jats:sup>2<\/jats:sup>\n              , 3.16 [95% CI, 3.00\u20133.33]), current smoking (1.58 [95% CI, 1.48\u20131.67]), prediabetes (1.21 [95% CI, 1.13\u20131.29]), diabetes (1.60 [95% CI, 1.41\u20131.81]) and high low\u2010density lipoprotein cholesterol (\u2265160 versus &lt;100\u2009mg\/dL, 1.52 [95% CI, 1.37\u20131.68]) were associated with the highest BP trajectory (group 5) compared with the reference group (group 2).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Traditional hypertension risk factors including smoking, diabetes, and elevated lipids were associated with BP trajectories in young adults, with obesity having the strongest association with the highest BP trajectory group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033053","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:53:18Z","timestamp":1712065998000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Young Adult Characteristics and Blood Pressure Trajectories"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5732","authenticated-orcid":false,"given":"Jaejin","family":"An","sequence":"first","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-0002","authenticated-orcid":false,"given":"Heidi","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1094-8068","authenticated-orcid":false,"given":"Liang","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8866-0057","authenticated-orcid":false,"given":"Mengying","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of General Medicine Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-662X","authenticated-orcid":false,"given":"Soon Kyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-0405","authenticated-orcid":false,"given":"Kerresa L.","family":"Morrissette","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-4982","authenticated-orcid":false,"given":"Rong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-1649","authenticated-orcid":false,"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5492","authenticated-orcid":false,"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-0563","authenticated-orcid":false,"given":"Monika M.","family":"Safford","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-0085","authenticated-orcid":false,"given":"Andrew E.","family":"Moran","sequence":"additional","affiliation":[{"name":"Division of General Medicine Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-6047","authenticated-orcid":false,"given":"Brandon K.","family":"Bellows","sequence":"additional","affiliation":[{"name":"Division of General Medicine Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-9593","authenticated-orcid":false,"given":"Carmen R.","family":"Isasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-4384","authenticated-orcid":false,"given":"Norrina B.","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-621X","authenticated-orcid":false,"given":"Vanessa","family":"Xanthakis","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University Chobanian and Avedisian School of Medicine Boston MA USA"},{"name":"Department of Biostatistics Boston University School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-1788","authenticated-orcid":false,"given":"Lisandro D.","family":"Colantonio","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-5001","authenticated-orcid":false,"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of General Medicine Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"1","article-title":"Hypertension prevalence among adults aged 18 and over: United States, 2017\u20102018","volume":"364","author":"Ostchega Y","year":"2020","unstructured":"Ostchega Y, Fryar CD, Nwankwo T, Nguyen DT. 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