{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:08Z","timestamp":1787018108294,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:sec id=\"jah39656-sec-0001\" sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Reinterventions may influence the outcomes of children with functionally single\u2010ventricle (f\u2010SV) congenital heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah39656-sec-0002\" xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We undertook a retrospective cohort study of children starting treatment for f\u2010SV between 2000 and 2018 in England, using the national procedure registry. Patients were categorized based on whether they survived free of transplant beyond 1 year of age. Among patients who had transplant\u2010free survival beyond 1 year of age, we explored the relationship between reinterventions in infancy and the outcomes of survival and Fontan completion, adjusting for complexity. Of 3307 patients with f\u2010SV, 909 (27.5%), had no follow\u2010up beyond 1 year of age, among whom 323 (35.3%) had \u22651 reinterventions in infancy. A total of 2398 (72.5%) patients with f\u2010SV had transplant\u2010free survival beyond 1 year of age, among whom 756 (31.5%) had \u22651 reinterventions in infancy. The 5\u2010year transplant\u2010free survival and cumulative incidence of Fontan, among those who survived infancy, were 93.4% (95% CI, 92.4%\u201394.4%) and 79.3% (95% CI, 77.4%\u201381.2%), respectively. Both survival and Fontan completion were similar for those with a single reintervention and those who had no reinterventions. Patients who had &gt;1 additional surgery (adjusted hazard ratio, 3.93 [95% CI, 1.87\u20138.27]\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) had higher adjusted risk of mortality. Patients who had &gt;1 additional interventional catheter (adjusted subdistribution hazard ratio, 0.71 [95% CI, 0.52\u20130.96]\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03) had a lower likelihood of achieving Fontan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah39656-sec-0003\" xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among children with f\u2010SV, the occurrence of &gt;1 reintervention in the first year of life, especially surgical reinterventions, was associated with poorer prognosis later in childhood.<\/jats:p>\n                  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