{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:41Z","timestamp":1790808221146,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              CONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION with no history of a cardiovascular event who delivered in France for the first time between 2010 and 2018 (N=2\u2009819\u2009655). Hypertensive disorders of pregnancy and cardiovascular outcomes during the study follow\u2010up were identified using algorithms combining\n              <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic>\n              (\n              <jats:italic>ICD\u201010<\/jats:italic>\n              ) coded diagnoses during hospitalization and purchases of medication between 2010 and 2021. We fitted Cox models with time\u2010varying exposure to assess the associations of hypertensive disorders of pregnancy with mortality and cardiovascular events. Women with gestational hypertension had a 1.25\u2010 to 2\u2010fold higher risk of stroke, acute coronary syndrome, peripheral arterial disease, pulmonary embolism, and chronic kidney disease, and a 2\u2010 to 4\u2010fold higher risk of rhythm and conduction disorder and heart failure. Women with preeclampsia had a 1.35\u2010 to 2\u2010fold higher risk of rhythm or conduction disorder and pulmonary embolism during follow\u2010up; a 2\u2010 to 4\u2010fold higher risk of stroke, acute coronary syndrome, and peripheral arterial disease; and a 7\u2010 to 9\u2010fold higher risk of heart failure and chronic kidney disease. They were 1.8 times more likely to die and 4.4 times more likely to die of cardiovascular causes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertensive disorders of pregnancy drastically increase the risk of mortality, cardiovascular, and renal events early after pregnancy. Recurrent, severe, and early\u2010onset preeclampsia further increases this risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033252","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:49:56Z","timestamp":1712065796000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-8804","authenticated-orcid":false,"given":"Gr\u00e9gory","family":"Lailler","sequence":"first","affiliation":[{"name":"Sant\u00e9 Publique France Saint\u2010Maurice France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil 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Epidemiology Research Team EPOP\u00e9, Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), INSERM Paris France"},{"name":"Maternit\u00e9 Port\u2010Royal FHU PREMA, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-8142","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"Plu\u2010Bureau","sequence":"additional","affiliation":[{"name":"Obstetrical Perinatal and Pediatric Epidemiology Research Team EPOP\u00e9, Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), INSERM Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Unit\u00e9 de Gyn\u00e9cologie M\u00e9dicale APHP, H\u00f4pital Port\u2010Royal Cochin Paris 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