{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:10Z","timestamp":1787018110100,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mobile health technology's impact on cardiovascular risk factor control is not fully understood. This study evaluates the association between interaction with a mobile health application and change in cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants with hypertension with or without dyslipidemia enrolled in a workplace\u2010deployed mobile health application\u2010based cardiovascular risk self\u2010management program between January 2018 and December 2022. Retrospective evaluation explored the influence of application engagement on change in blood pressure (BP), total cholesterol (TC), low\u2010density lipoprotein cholesterol (LDL\u2010C), and weight. Multiple regression analyses examined the influence of guideline\u2010based, nonpharmacological lifestyle\u2010based digital coaching on outcomes adjusting for confounders. Of 102\u2009475 participants, 49.1% were women. Median age was 53 (interquartile range, 43\u201361) years, BP was 134 (interquartile range, 124\u2013144)\/84 (interquartile range, 78\u201391) mm\u2009Hg, TC was 183 (interquartile range, 155\u2013212) mg\/dL, LDL\u2010C was 106 (82\u2013131) mg\/dL, and body mass index was 30 (26\u201335) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . At 2\u2009years, participants with baseline systolic BP \u2265140\u2009mm\u2009Hg reduced systolic BP by 18.6 (SEM, 0.3) mm\u2009Hg. At follow up, participants with baseline TC \u2265240\u2009mg\/dL reduced TC by 65.7 (SEM, 4.6) mg\/dL, participants with baseline LDL\u2010C\u2265160\u2009mg\/dL reduced LDL\u2010C by 66.6 (SEM, 6.2) mg\/dL, and participants with baseline body mass index \u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      lost 12.0 (SEM, 0.3) pounds, or 5.1% of body weight. Interaction with digital coaching was associated with greater reduction in all outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">A mobile health application\u2010based cardiovascular risk self\u2010management program was associated with favorable reductions in BP, TC, LDL\u2010C, and weight, highlighting the potential use of this technology in comprehensive cardiovascular risk factor control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033328","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:07:30Z","timestamp":1715926050000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Comprehensive Cardiovascular Risk Factor Control With a Mobile Health Cardiovascular Risk Self\u2010Management Program"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4501-0746","authenticated-orcid":false,"given":"Edo","family":"Paz","sequence":"first","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-6560","authenticated-orcid":false,"given":"Vedant S.","family":"Pargaonkar","sequence":"additional","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-1465","authenticated-orcid":false,"given":"Brian J.","family":"Roach","sequence":"additional","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Meadows","sequence":"additional","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Gazit","sequence":"additional","affiliation":[{"name":"Hello Heart, Inc Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-819X","authenticated-orcid":false,"given":"Amanda L.","family":"Zaleski","sequence":"additional","affiliation":[{"name":"Clinical Evidence Development, Aetna Medical Affairs, CVS Health\u00ae Hartford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-2795","authenticated-orcid":false,"given":"Kelly Jean Thomas","family":"Craig","sequence":"additional","affiliation":[{"name":"Clinical Evidence Development, Aetna Medical Affairs, CVS Health\u00ae Hartford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2037-2225","authenticated-orcid":false,"given":"Steven J.","family":"Serra","sequence":"additional","affiliation":[{"name":"Aetna Commercial, Clinical Business Support CVS Health Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-8335","authenticated-orcid":false,"given":"Pat","family":"Dunn","sequence":"additional","affiliation":[{"name":"American Heart Association Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-5084","authenticated-orcid":false,"given":"Erin D.","family":"Michos","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_3_2_4_2","first-page":"1","article-title":"Hypertension prevalence among adults aged 18 and over: United States, 2017\u20132018","volume":"364","author":"Ostchega Y","year":"2020","unstructured":"Ostchega Y, Fryar CD, Nwankwo T, Nguyen DT. 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