{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:41:49Z","timestamp":1793011309133,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Outcomes from cardiopulmonary resuscitation (CPR) following sudden cardiac arrest are suboptimal. Postresuscitation targeted temperature management has been shown to have benefit in subjects with sudden cardiac arrest due to ventricular fibrillation, but there are few data for outcomes from sudden cardiac arrest due to pulseless electrical activity. In addition, intra\u2010CPR cooling is more effective than postresuscitation cooling. Physical cooling is associated with increased protein kinase B activity. Therefore, our group developed a novel peptide, TAT\u2010PHLPP9c, which regulates protein kinase B. We hypothesized that when given during CPR, TAT\u2010PHLPP9c would improve survival and neurologic outcomes following pulseless electrical activity arrest.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 24 female pigs, pulseless electrical activity was induced by inflating balloon catheters in the right coronary and left anterior descending arteries for \u22487\u2009minutes. Advanced life support was initiated. In 12 control animals, epinephrine was given after 1 and 3\u2009minutes. In 12 peptide\u2010treated animals, 7.5 mg\/kg TAT\u2010PHLPP9c was also administered at 1 and 3\u2009minutes of CPR. The balloons were removed after 2\u2009minutes of support. Animals were recovered and neurologically scored 24\u2009hours after return of spontaneous circulation. Return of spontaneous circulation was more common in the peptide group, but this difference was not significant (8\/12 control versus 12\/12 peptide;\n              <jats:italic>P<\/jats:italic>\n              =0.093), while fully intact neurologic survival was significantly more common in the peptide group (0\/12 control versus 11\/12 peptide;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.00001). TAT\u2010PHLPP9c significantly increased myocardial nicotinamide adenine dinucleotide levels.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">TAT\u2010PHLPP9c resulted in improved survival with full neurologic function after sudden cardiac arrest in a swine model of pulseless electrical activity, and the peptide shows potential as an intra\u2010CPR pharmacologic agent.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033371","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:13:38Z","timestamp":1719497618000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Survival and Neurologic Outcomes From Pharmacologic Peptide Administration During Cardiopulmonary Resuscitation of Pulseless Electrical 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