{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:07:44Z","timestamp":1792066064058,"version":"4.4.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although stroke is commonly perceived as occurring in older adults, traumatic brain injury, one of the risk factors for stroke, is a leading cause of death in the younger adults. This study evaluated stroke risk in young\u2010to\u2010middle\u2010aged adults based on traumatic brain injury severity and stroke subtypes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              For this retrospective, population\u2010based, cohort study, data of adults aged 18 to 49\u2009years who were diagnosed with traumatic brain injury were obtained from the Korean National Health Insurance Service between 2010 and 2017. Traumatic brain injury history was measured based on the\n              <jats:italic>International Classification of Diseases<\/jats:italic>\n              ,\n              <jats:italic>Tenth Revision (ICD\u201010)<\/jats:italic>\n              , codes. Posttraumatic brain injury stroke risk was analyzed using a time\u2010dependent Cox regression model. At baseline, 518423 patients with traumatic brain injury and\u2009518\u2009423 age\u2010 and sex\u2010matched controls were included. The stroke incidence rate per 1000 person\u2010years was 3.82 in patients with traumatic brain injury and 1.61 in controls. Stroke risk was approximately 1.89 times as high in patients with traumatic brain injury (hazard ratio, 1.89 [95% CI, 1.84\u20131.95]). After excluding stroke cases that occurred within 12\u2009months following traumatic brain injury, these significant associations remained. In the subgroup analysis, patients with brain injury other than concussion had an approximately 9.34\u2010fold risk of intracerebral hemorrhage than did the controls.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Stroke prevention should be a priority even in young\u2010to\u2010middle\u2010aged adult patients with traumatic brain injury. Managing stroke risk factors through regular health checkups and modifying health\u2010related behaviors is necessary to prevent stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033453","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T11:12:32Z","timestamp":1723547552000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Elevated Risk of Stroke in Young Adults After Traumatic Brain Injury: A Nationwide Study of 1\u2009Million Individuals"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-9215","authenticated-orcid":false,"given":"Yoonjeong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital Seoul Republic of Korea"},{"name":"National Traffic Injury Rehabilitation Research Institute, National Traffic Injury Rehabilitation Hospital Yangpyeong 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