{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:07:33Z","timestamp":1780967253376,"version":"3.54.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In older adults, obstructive sleep apnea (OSA) has been associated with several cardiovascular complications. Whether young patients diagnosed with OSA also are at higher risk of developing subsequent cardiovascular disease is uncertain. We aimed to estimate the risk of developing an incident cardiovascular event among young patients diagnosed with OSA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We linked nationwide Danish health registries to identify a cohort of patients aged \u226450\u2009years with OSA using data from 2010 through 2018. Cases without OSA from the general population were matched as controls (1:5). The main outcome was any cardiovascular event (including hypertension, diabetes, atrial fibrillation, ischemic heart disease, ischemic stroke, heart failure, and venous thromboembolism). All\u2010cause mortality was a secondary outcome. The study included 20\u2009240 patients aged \u226450 years with OSA (19.6% female; mean\u00b1SD age 39.9\u00b17.7\u2009years) and 80\u2009314 controls. After 5\u2010year follow\u2010up, 31.8% of the patients with OSA developed any cardiovascular event compared with 16.5% of the controls, with a corresponding relative risk (RR) of 1.96 (95% CI, 1.90\u20132.02). At 5\u2010year follow\u2010up, 27.3% of patients with OSA developed incident hypertension compared with 15.0% of the controls (RR, 1.84 [95% CI, 1.78\u20131.90]). Incident diabetes occurred in 6.8% of the patients with OSA and 1.4% of controls (RR, 5.05 [95% CI, 4.60\u20135.54]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Similar to older adults, young adults with OSA demonstrate increased risk of developing cardiovascular events. To prevent cardiovascular disease progression, accumulation of cardiovascular risk factors, and mortality, risk stratification and prevention strategies should be considered for these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033506","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:52:48Z","timestamp":1712065968000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Cardiovascular Risk in Young Patients Diagnosed With Obstructive Sleep Apnea"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-8116","authenticated-orcid":false,"given":"Ida E.","family":"Albertsen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Audiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Bille","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Audiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-5276","authenticated-orcid":false,"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Department of Clinical Medicine Danish Center for Health Services Research Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-6970","authenticated-orcid":false,"given":"Peter B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Danish Center for Health Services Research Aalborg University Aalborg Denmark"},{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200709-155MG"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4732"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S101969"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000988"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.5837\/bjc.2022.010"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.05.021"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.08.021"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.069"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014458"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_3_1_14_2","article-title":"Validity of obstructive sleep apnea diagnoses in the Danish National Patient Register","author":"Ofverlind E","unstructured":"Ofverlind E, Bille J, Overvad TF, Nielsen PB, Albertsen IE. 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