{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:35:40Z","timestamp":1774416940312,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The incidental use of statins during radiation therapy has been associated with a reduced long\u2010term risk of developing atherosclerotic cardiovascular disease. We examined whether irradiation causes chronic vascular injury and whether short\u2010term administration of statins during and after irradiation is sufficient to prevent chronic injury compared with long\u2010term administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      C57Bl\/6 mice were pretreated with pravastatin for 72\u2009hours and then exposed to 12 Gy X\u2010ray head\u2010and\u2010neck irradiation. Pravastatin was then administered either for an additional 24\u2009hours or for 1\u2009year. Carotid arteries were tested for vascular reactivity, altered gene expression, and collagen deposition 1\u2009year after irradiation. Treatment with pravastatin for 24\u2009hours after irradiation reduced the loss of endothelium\u2010dependent vasorelaxation and protected against enhanced vasoconstriction. Expression of markers associated with inflammation (NF\u03baB p65 [phospho\u2010nuclear factor kappa B p65] and TNF\u2010\u03b1 [tumor necrosis factor alpha]) and with oxidative stress (NADPH oxidases 2 and 4) were lowered and subunits of the voltage and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      activated K\n                      <jats:sup>+<\/jats:sup>\n                      BK channel (potassium calcium\u2010activated channel subfamily M alpha 1 and potassium calcium\u2010activated channel subfamily M regulatory beta subunit 1) in the carotid artery were modulated. Treatment with pravastatin for 1\u2009year after irradiation completely reversed irradiation\u2010induced changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Short\u2010term administration of pravastatin is sufficient to reduce chronic vascular injury at 1\u2009year after irradiation. Long\u2010term administration eliminates the effects of irradiation. These findings suggest that a prospective treatment strategy involving statins could be effective in patients undergoing radiation therapy. The optimal duration of treatment in humans has yet to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033558","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T06:54:59Z","timestamp":1718952899000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Short\u2010Term Statin Treatment Reduces, and Long\u2010Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7133-4767","authenticated-orcid":false,"given":"Karima","family":"Ait\u2010Aissa","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Dental Medicine Lincoln Memorial University Knoxville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xutong","family":"Guo","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelyn","family":"Klemmensen","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8089-7818","authenticated-orcid":false,"given":"Denise","family":"Juhr","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linette N.","family":"Leng","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-0046","authenticated-orcid":false,"given":"Olha M.","family":"Koval","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-3157","authenticated-orcid":false,"given":"Isabella M.","family":"Grumbach","sequence":"additional","affiliation":[{"name":"Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA"},{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine University of Iowa Iowa City IA USA"},{"name":"Iowa City VA Healthcare System Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht114"},{"key":"e_1_3_2_3_2","first-page":"306","article-title":"Radiation\u2010induced arterial injuries","volume":"93","author":"McCready RA","year":"1983","unstructured":"McCready RA, Hyde GL, Bivins BA, Mattingly SS, Griffen WO. Radiation\u2010induced arterial injuries. Surgery. 1983;93:306\u2013312.","journal-title":"Surgery"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.282"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100139167"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197801)41:1<130::aid-cncr2820410121>3.0.co;2-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.08.031"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.01802"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005996"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1133315"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.047"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000080895.05158.8B"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009414550041"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01280.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.03.035"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4192"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aacdcd"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.12.019"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014668"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2017.0075"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600620R"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.053"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.317869"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz206"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000198399.40584.8c"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12038"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01190-6"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.6.635"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705079"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00112-6"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e3282f3fbde"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000051384.43104.fc"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.24266"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14172"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2011.12.005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3109\/09553000903564042"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553000601146931"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00748.2004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-1974-6"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1522-1865(98)00010-9"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.02.024"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051897"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00020"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.806081"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11070-x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.033558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T09:16:37Z","timestamp":1730798197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.033558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":44,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7,2]]}},"alternative-id":["10.1161\/JAHA.123.033558"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.033558","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.20.558723","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"assertion":[{"value":"2023-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e033558"}}