{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:17:51Z","timestamp":1792271871595,"version":"4.4.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Evidence guiding the pre\u2010hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. We sought to derive and validate a pre\u2010HSCT score for the cardiovascular risk stratification of HSCT candidates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We leveraged the CARE\u2010BMT (Cardiovascular Registry in Bone Marrow Transplantation) study, a contemporary multicenter observational study of adult patients who underwent autologous or allogeneic HSCT between 2008 and 2019 (N=2435; mean age at transplant of 55\u2009years; 4.9% Black). We identified the subset of variables most predictive of post\u2010HSCT cardiovascular events, defined as a composite of cardiovascular death, myocardial infarction, heart failure, stroke, atrial fibrillation or flutter, and sustained ventricular tachycardia. We then developed a point\u2010based risk score using the hazard ratios obtained from Cox proportional hazards modeling. The score was externally validated in a separate cohort of 919 HSCT recipients (mean age at transplant 54 years; 20.4% Black). The risk score included age, transplant type, race, coronary artery disease, heart failure, peripheral artery disease, creatinine, triglycerides, and prior anthracycline dose. Risk scores were grouped as low\u2010, intermediate\u2010, and high\u2010risk, with the 5\u2010year cumulative incidence of cardiovascular events being 4.0%, 10.3%, and 22.4%, respectively. The area under the receiver operating curves for predicting cardiovascular events at 100\u2009days, 5 and 10\u2009years post\u2010HSCT were 0.65 (95% CI, 0.59\u20130.70), 0.73 (95% CI, 0.69\u20130.76), and 0.76 (95% CI, 0.69\u20130.81), respectively. The model performed equally well in autologous and allogeneic recipients, as well as in the validation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The CARE\u2010BMT risk score is easy to calculate and could help guide referrals of high\u2010risk HSCT recipients to cardiovascular specialists before transplant and guide long\u2010term monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033599","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T20:36:06Z","timestamp":1703882166000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Cardiovascular Risk Stratification of Patients Undergoing Hematopoietic Stem Cell Transplantation: The CARE\u2010BMT Risk Score"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-5364","authenticated-orcid":false,"given":"Alexi","family":"Vasbinder","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonimarie","family":"Catalan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-1544","authenticated-orcid":false,"given":"Elizabeth","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chu","sequence":"additional","affiliation":[{"name":"Rush University Medical College, Rush University Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kotzin","sequence":"additional","affiliation":[{"name":"Rush University Medical College, Rush University Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-9173","authenticated-orcid":false,"given":"Danielle","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-2269","authenticated-orcid":false,"given":"Halle","family":"Cheplowitz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Rush University Medical Center Chicago 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