{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:44:29Z","timestamp":1792698269356,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Minimally invasive mitral valve repair has a favorable risk\u2013benefit profile in patients with significant de novo mitral regurgitation. Its role in patients with prior mitral valve repair is uncertain. We aimed to appraise the outcome of patients undergoing transcatheter edge\u2010to\u2010edge repair (TEER) with prior transcatheter or surgical mitral valve repair (SMVR).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We queried the Italian multicenter registry on TEER with MitraClip, distinguishing na\u00efve patients from those with prior TEER or (SMVR). Inhospital and long\u2010term clinical\/echocardiographic outcomes were appraised. The primary outcome was the occurrence of death or rehospitalization for heart failure. A total of 2238 patients were included, with 2169 (96.9%) who were na\u00efve to any mitral intervention, 29 (1.3%) with prior TEER, and 40 (1.8%) with prior SMVR. Several significant differences were found in baseline clinical and imaging features. Respectively, device success was obtained in 2120 (97.7%), 28 (96.6%), and 38 (95.0%,\n              <jats:italic>P<\/jats:italic>\n              =0.261) patients; procedural success in 2080 (95.9%), 25 (86.2%), and 38 (95.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.047); and inhospital death in 61 (2.8%), 1 (3.5%), and no (\n              <jats:italic>P<\/jats:italic>\n              =0.558) patients. Clinical follow\u2010up after a mean of 14\u2009months showed similar rates of death, cardiac death, rehospitalization, rehospitalization for heart failure, and their composite (all\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). Propensity score\u2013adjusted analysis confirmed unadjusted analysis, with lower procedural success for the prior TEER group (odds ratio, 0.28 [95% CI, 0.09\u20130.81];\n              <jats:italic>P<\/jats:italic>\n              =0.019) but similar odds ratios and hazard ratios for all other outcomes in the na\u00efve, TEER, and SMVR groups (all\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In carefully selected patients, TEER can be performed using the MitraClip device even after prior TEER or SMVR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033605","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:01:20Z","timestamp":1715680880000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Transcatheter Mitral Valve Repair With the MitraClip Device for Prior Mitral Valve Repair Failure: Insights From the GIOTTO\u2010FAILS Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-8736","authenticated-orcid":false,"given":"Arturo","family":"Giordano","sequence":"first","affiliation":[{"name":"Unit\u00e0 Operativa di Interventistica Cardiovascolare Pineta Grande Hospital Castel Volturno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Emodinamica Santa Lucia Hospital San Giuseppe Vesuviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5833-4791","authenticated-orcid":false,"given":"Filippo","family":"Finizio","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Interventistica Cardiovascolare Pineta Grande Hospital Castel Volturno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-274X","authenticated-orcid":false,"given":"Nicola","family":"Corcione","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Interventistica Cardiovascolare Pineta Grande Hospital Castel Volturno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-0178","authenticated-orcid":false,"given":"Michele","family":"Cimmino","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Interventistica Cardiovascolare Pineta Grande Hospital Castel Volturno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-8510","authenticated-orcid":false,"given":"Giuseppe","family":"Biondi\u2010Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medico\u2010Surgical Sciences and Biotechnologies Sapienza University of Rome Latina Italy"},{"name":"Mediterranea Cardiocentro Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-0203","authenticated-orcid":false,"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-4626","authenticated-orcid":false,"given":"Antonio Popolo","family":"Rubbio","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato, San Donato Milanese Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-4553","authenticated-orcid":false,"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department University Hospital Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Bartorelli","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS Milan Italy"},{"name":"Department of Biomedical and Clinical Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Mongiardo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical and Surgical Sciences \"Magna Graecia\" University Catanzaro 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Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology ASST Spedali Civili di Brescia Brescia Italy"},{"name":"Department of Medical and Surgical Specialties, Radiological Sciences Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-9459","authenticated-orcid":false,"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit IRCCS San Raffaele Scientific Institute, Vita Salute San Raffaele University Milan Italy"},{"name":"Thoracic\u2010Vascular Department San Raffaele University Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Baldi","sequence":"additional","affiliation":[{"name":"Heart Department University Hospital \u2018Scuola Medica Salernitana\u2019 Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-2917","authenticated-orcid":false,"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Science, Interventional Cardiology Unit University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1410","authenticated-orcid":false,"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Division of Cardiology IRCCS Ospedale Galeazzi\u2014Sant\u2019Ambrogio Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ronco","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Department of Cardio\u2010Thoracic and Vascular Sciences Ospedale dell\u2019Angelo, AULSS3 Serenissima Venezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-1613","authenticated-orcid":false,"given":"Ida","family":"Monteforte","sequence":"additional","affiliation":[{"name":"Divisione di Cardiologia A.O. dei Colli, Ospedale Monaldi Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3446-7832","authenticated-orcid":false,"given":"Emmanuel","family":"Villa","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit and Valve Center Poliambulanza Foundation Hospital Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Ferrario","sequence":"additional","affiliation":[{"name":"Division of Cardiology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fiocca","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Castriota","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit GVM Care &amp; Research, Maria Cecilia Hospital Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-5443","authenticated-orcid":false,"given":"Angelo","family":"Squeri","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit GVM Care &amp; Research, Maria Cecilia Hospital Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-9742","authenticated-orcid":false,"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Centro Alte Specialit\u00e0 e Trapianti (CAST) Azienda Ospedaliero\u2010Universitaria Policlinico\u2010Vittorio Emanuele, University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato, San Donato Milanese Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa768"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029553"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.23.04827-9"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.10.006"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2133"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1616"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.04.107"},{"key":"e_1_3_1_11_2","first-page":"589","article-title":"Reduction of mitral valve regurgitation with Mitraclip\u00ae percutaneous system","volume":"58","author":"Tamburino C","year":"2010","unstructured":"Tamburino C, Imm\u00e8 S, Barbanti M, Mul\u00e8 M, Pistritto AM, Aruta P, Cammalleri V, Scarabelli M, Mangiafico S, Scandura S, et\u00a0al. 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