{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:31:20Z","timestamp":1753889480999,"version":"3.41.2"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:sec id=\"jah39866-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Few small\u2010sample studies have quantified the T\u2010wave alternans (TWA) value by 24\u2010hour ambulatory recordings or exercise stress tests in patients with long QT syndrome (LQTS). The cutoff point of TWA \u226547\u2009\u03bcV was based on patients with myocardial infarction. In our study, we aimed to (1) evaluate the association of TWA with life\u2010threatening arrhythmic events (LAEs); (2) compare the predictive model of LAEs according to the TWA value measured by 24\u2010hour ambulatory recordings and exercise stress tests; and (3) propose a cutoff point for the high risk of LAEs in patients with LQTS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah39866-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study cohort included 110 patients with LQTS referred to our hospital, and the primary outcome was LAEs. Thirty\u2010one patients with LQTS (31\/110 [28.2%]) developed LAEs during the following 24 (12\u201347) months. Peak TWA value quantified from 12 leads by 24\u2010hour ambulatory recordings in patients with LQTS with LAEs (LQTS\u2013LAEs group) was significantly higher than LQTS without LAEs (LQTS\u2013non\u2010LAEs group) (64.0 [42.0\u201386.0] \u03bcV versus 43.0 [36.0\u201353.0] \u03bcV;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.01). There was no statistical difference in TWA value measured by exercise stress tests between the 2 groups (69.0 [54.5\u2013127.5] \u03bcV versus 68.5 [53.3\u201399.8] \u03bcV;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.871). The new cutoff point of the peak TWA value measured by 24\u2010hour ambulatory recordings was 55.5 \u03bcV, with a sensitivity of 75.0% and a specificity of 78.6%. A univariate Cox regression analysis revealed that TWA value \u226555.5\u2009\u03bcV was a strong predictor of LAEs (hazard ratio [HR], 4.5 [2.1\u20139.6];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001]. A multivariate Cox regression analysis indicated that TWA value \u226555.5\u2009\u03bcV remained significant (HR, 2.7 [1.1\u20136.8];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.034).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah39866-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Peak TWA measured by 24\u2010hour ambulatory recordings was a more favorable risk stratification marker than exercise stress tests for patients with LQTS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033619","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:57:25Z","timestamp":1720526245000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010Wave Alternans Measured by 24\u2010Hour Ambulatory Recordings Rather Than Exercise Stress Tests as a Risk Stratification Marker in Patients With Long QT Syndrome"],"prefix":"10.1161","volume":"13","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangying","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1945-0779","authenticated-orcid":false,"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-124X","authenticated-orcid":false,"given":"Tingting","family":"Lv","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"She","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-1108","authenticated-orcid":false,"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University","place":["Beijing, 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