{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:38:38Z","timestamp":1791337118623,"version":"4.3.1"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sinus venosus atrial septal defect (SVASD) is a rare congenital cardiac anomaly comprising 5% to 10% of all atrial septal defects. Although surgical closure is the standard treatment for SVASD, data on outcomes have been confined to small cohorts. Thus, we conducted a systematic review of the outcomes of SVASD repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The primary outcome was death. Secondary outcomes encompassed atrial fibrillation, sinus node dysfunction, pacemaker insertion, cerebrovascular accident, reoperation, residual septal defect, superior vena cava obstruction, and reimplanted pulmonary vein obstruction. Pooled incidences of outcomes were calculated using a random\u2010effects model. Forty\u00a0studies involving 1320 patients who underwent SVASD repair were included. The majority were male patients (55.4%), with 88.0% presenting with associated anomalous pulmonary venous connection. The weighted mean age was\u00a018.6\u00b112.5\u2009years, and the overall weighted mean follow\u2010up period was 8.6\u00b110.4\u2009years. The in\u2010hospital mortality rate was 0.24%, with a 30\u2010day mortality rate of 0.5% reported in 780 patients. Incidences of atrial fibrillation, sinus node dysfunction, pacemaker insertion, and cerebrovascular accident over the long\u2010term follow\u2010up were 3.3% (2.18%\u20134.93%), 6.5% (5.09%\u20138.2%), 2.23% (1.34%\u20133.57%), and 2.03% (0.89%\u20132.46%) respectively. Reoperation occurred in 1.36% (0.68%\u20132.42%) of surgeries, residual septal defect in 1.34% (0.69%\u20132.42%), superior vena cava obstruction in 1.76% (1.02%\u20132.9%), and reimplanted pulmonary vein obstruction in 1.4% (0.7%\u20132.49%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This is the first comprehensive analysis of outcomes following surgical repair of SVASD. The findings affirm the safety and effectiveness of surgery, establishing a reference point for evaluating emerging transcatheter therapies. Safety and efficacy profiles comparable\u00a0to surgical repair are essential for widespread adoption of transcatheter treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033686","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:09:22Z","timestamp":1718348962000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Outcomes Following Surgical Repair of Sinus Venosus Atrial Septal Defects: A\u00a0Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-4337","authenticated-orcid":false,"given":"Ryaan","family":"El\u2010Andari","sequence":"first","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-7114","authenticated-orcid":false,"given":"Muhammad","family":"Moolla","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-0294","authenticated-orcid":false,"given":"Kevin","family":"John","sequence":"additional","affiliation":[{"name":"Tufts University","place":["Medford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7056-5226","authenticated-orcid":false,"given":"Ashley","family":"Slingerland","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-3880","authenticated-orcid":false,"given":"Sandra","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Alberta Library","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-6717","authenticated-orcid":false,"given":"Jeevan","family":"Nagendran","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-2014","authenticated-orcid":false,"given":"Yongzhe","family":"Hong","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-1419","authenticated-orcid":false,"given":"Anoop","family":"Mathew","sequence":"additional","affiliation":[{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu088"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00304"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30447"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.070"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26031"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.493775"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs369"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12810"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2011.07.017"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(10)62317-x"},{"key":"e_1_3_1_12_2","volume-title":"Newcastle\u2010Ottawa Quality Assessment Scale Cohort Studies","author":"Wells GA","year":"2014","unstructured":"Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. 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