{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:55:53Z","timestamp":1789473353548,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Periodontitis has not been recognized as a modifiable risk factor for atrial fibrillation (AF). This prospective nonrandomized study investigated whether periodontal treatment improves the AF ablation outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We prospectively enrolled 288 AF patients scheduled to undergo initial radiofrequency catheter ablation. Each patient underwent periodontal inflamed surface area (PISA; a quantitative index of periodontal inflammation) measurement. All eligible patients were recommended to receive periodontal treatment within the blanking period, and 97 consented. During the mean follow\u2010up period of 507\u00b1256\u2009days, 70 (24%) AF recurrences were documented. Patients who exhibited AF recurrences had a higher PISA than those who did not (456.8\u00b1403.5 versus 277.7\u00b1259.0\u2009mm\n              <jats:sup>2<\/jats:sup>\n              ,\n              <jats:italic>P<\/jats:italic>\n              =0.001). These patients were categorized into high\u2010PISA (&gt;615\u2009mm\n              <jats:sup>2<\/jats:sup>\n              ) and low\u2010PISA (&lt;615\u2009mm\n              <jats:sup>2<\/jats:sup>\n              ) groups according to the receiver operating characteristic analysis for AF recurrence (area under the curve, 0.611; sensitivity, 39%; specificity, 89%). A high PISA, as well as female sex, AF duration, and left atrial volume, were the statistically significant predicter for AF recurrence (hazard ratio [HR], 2.308 [95% CI, 1.234\u20134.315];\n              <jats:italic>P<\/jats:italic>\n              =0.009). In patients with a high PISA, those who underwent periodontal treatment showed significantly fewer AF recurrences (\n              <jats:italic>P<\/jats:italic>\n              =0.01, log\u2010rank test). The adjusted HR of periodontal treatment for AF recurrence was 0.393 (95% CI, 0.215\u20130.719;\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Periodontitis may serve as a modifiable risk factor for AF. PISA is a hallmark of AF recurrence, and periodontal treatment improves the AF ablation outcome, especially for those with poor periodontal condition.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033740","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T09:30:17Z","timestamp":1712741417000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-3182","authenticated-orcid":false,"given":"Shunsuke","family":"Miyauchi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"},{"name":"Division of Medicine, Health Service Center Hiroshima University Higashihiroshima 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