{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:07:32Z","timestamp":1778177252559,"version":"3.51.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertension and hypercholesterolemia are important risk factors for cardiovascular disease, and treatment with fixed\u2010dose combination (FDC) regimens is recommended by current guidelines. However, the clinical outcomes of different FDC dosages remain unknown. This study aimed to examine the clinical outcomes of FDC regimens and the free combination of amlodipine and atorvastatin at different dosages.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with concurrent hypertension and hypercholesterolemia treated daily with an FDC of 5\u2009mg amlodipine and 10\u2009mg atorvastatin (5\/10 fixed group), and FDC of 5\u2009mg amlodipine and 20\u2009mg atorvastatin (5\/20 fixed group), or free combination of 5\u2009mg amlodipine and 20\u2009mg atorvastatin (5\/20 free group) were identified from the National Health Insurance Research Database of Taiwan. The primary outcome was the composite cardiovascular outcomes, including cardiovascular death, acute myocardial infarction, stroke, and coronary intervention. A total of 9095 patients were eligible for inclusion. The incidence of primary outcome per 1000 person\u2010years was 16.6 in the 5\/10 fixed group, 12.6 in the 5\/20 fixed group, and 16.5 in the 5\/20 free group (5\/20 fixed versus 5\/20 free: hazard ratio [HR], 0.76 [95% CI, 0.64\u20130.91]; 5\/20 fixed versus 5\/10 fixed: HR, 0.76 [95% CI, 0.63\u20130.90]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with concomitant hypertension and hypercholesterolemia, treatment with an FDC of amlodipine and high\u2010dose atorvastatin led to a lower risk of a composite of cardiovascular outcomes than treatment with the free combination or a similar FDC with a lower dose of atorvastatin.<\/jats:p>\n          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