{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:36:00Z","timestamp":1792690560134,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Magnetic resonance imaging infarct topography may assist with determining stroke etiology. The influence of diffusion\u2010weighted imaging (DWI)\u2010positive lesions on etiology determination in patients with transient ischemic attack or minor stroke is not well studied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We prospectively enrolled patients between 2010 and 2017 in 2 studies; participants with a final diagnosis of probable or definite transient ischemic attack or stroke were pooled for analysis. The primary outcome was the adjudicated ischemic etiology. We compared proportion of each etiology (cardioembolic, large\u2010vessel, small\u2010vessel disease, other) in patients who had DWI positivity compared with DWI negativity. We used logistic regression to determine the adjusted odds ratio (OR) for each etiology compared with undetermined by DWI positivity. The final analysis included 1498 patients: 832 (55.5%) were DWI\u2010positive. DWI\u2010positive patients were more likely to be diagnosed with small\u2010vessel disease (19.1% versus 5.3%) and less likely with undetermined etiology (36.9% versus 53.0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). After adjustment, the presence of any DWI lesion was associated with increased odds of assigning any etiology (OR, 1.8 [95% CI, 1.3\u20132.5]). A single DWI lesion was associated with increased odds of small\u2010vessel disease diagnosis (OR, 9.5 [95% CI, 6.4\u201314.0]), and multiple DWI lesions with reduced odds of small\u2010vessel disease (OR, 0.2 [95% CI, 0.1\u20130.4]) but increased odds of all other etiologies compared with undetermined etiology.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Any DWI\u2010positive lesion after suspected transient ischemic attack or minor stroke was associated with increased odds of assigning a etiology. Presence and topography of DWI lesions on magnetic resonance imaging may assist with etiology determination and may impact stroke prevention therapies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.033817","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T12:00:00Z","timestamp":1711540800000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Magnetic Resonance Imaging Assists With Determining Etiology After Transient Ischemic Attack or Minor Stroke"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-6944","authenticated-orcid":false,"given":"Margaret","family":"Moores","sequence":"first","affiliation":[{"name":"Kelowna General Hospital &amp; University of British Columbia Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-0701","authenticated-orcid":false,"given":"Raed A.","family":"Joundi","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-0904","authenticated-orcid":false,"given":"Nishita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Neurology Division), Rady Faculty of Health Sciences University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6474-0827","authenticated-orcid":false,"given":"Andrew M.","family":"Penn","sequence":"additional","affiliation":[{"name":"Stroke Rapid Assessment Unit, Island Health Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4912-5838","authenticated-orcid":false,"given":"Kristine","family":"Votova","sequence":"additional","affiliation":[{"name":"Island Health Regional Health Authority, Division of Medical Sciences University of Victoria Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-1668","authenticated-orcid":false,"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-5105","authenticated-orcid":false,"given":"Shelagh B.","family":"Coutts","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333286"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.680033"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-018-2029-x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027861"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00132-5"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007531"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.606521"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613752"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.12.1730"},{"key":"e_1_3_1_11_2","first-page":"35","article-title":"Contribution of diffusion\u2010weighted imaging in determination of stroke etiology","volume":"27","author":"Wessels T","year":"2006","unstructured":"Wessels T, Wessels C, Ellsiepen A, Reuter I, Trittmacher S, Stolz E, Jauss M. Contribution of diffusion\u2010weighted imaging in determination of stroke etiology. Am J Neuroradiol. 2006;27:35\u201339.","journal-title":"Am J Neuroradiol"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03080.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x-anp-2021-0080"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3063"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1305"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25556"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.033817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:38:19Z","timestamp":1715603899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.033817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.1161\/JAHA.123.033817"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.033817","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e033817"}}