{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:11:53Z","timestamp":1793250713441,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Dapagliflozin, a sodium\u2013glucose cotransporter 2 inhibitor, is an epochal oral antidiabetic drug that improves cardiorenal outcomes. However, the effect of early dapagliflozin intervention on left ventricular (LV) remodeling in patients with type 2 diabetes free from cardiovascular disease remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The ELUCIDATE trial was a prospective, open\u2010label, randomized, active\u2010controlled study that enrolled 76 patients with asymptomatic type 2 diabetes with LV ejection fraction \u226550%, randomized to the dapagliflozin 10\u2009mg\/day add\u2010on or standard\u2010of\u2010care group. Speckle\u2010tracking echocardiography\u2013based measurements of the cardiac global longitudinal strain were performed at baseline and 24\u2009weeks after treatment initiation. Patients who received dapagliflozin had a greater reduction in LV dimension (1.68\u2009mm [95% CI, 0.53\u20132.84];\n                      <jats:italic>P<\/jats:italic>\n                      =0.005), LV end\u2010systolic volume (5.51\u2009mL [95% CI, 0.86\u201310.17];\n                      <jats:italic>P<\/jats:italic>\n                      =0.021), and LV mass index (4.25\u2009g\/m\n                      <jats:sup>2.7<\/jats:sup>\n                      [95% CI, 2.42\u20136.09];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) compared with standard of care in absolute mean differences. Dapagliflozin add\u2010on therapy led to a significant LV global longitudinal strain increment (0.74% [95% CI, 1.00\u20130.49];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) and improved LV systolic and early diastolic strain rates (0.27\/s [95% CI, 0.17\u20130.60]; and 0.11\/s [95% CI, 0.06\u20130.16], respectively; both\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) but not in global circumferential strain. No significant changes were found in insulin resistance, NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) levels, or other biomarkers at 6\u2009months after the dapagliflozin administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Dapagliflozin add\u2010on therapy could lead to more favorable cardiac remodeling accompanied by enhanced cardiac mechanical function among patients with asymptomatic type 2 diabetes. Our findings provide evidence of the efficacy of dapagliflozin use for the primary prevention of diabetic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03871621.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.033832","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T07:15:12Z","timestamp":1713510912000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["ELUCIDATE Trial: A Single\u2010Center Randomized 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