{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:31:07Z","timestamp":1758274267138,"version":"3.41.2"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The authors aimed to elucidate the relationship between latest ischemic event and the incidence of subsequent ischemic stroke in patients with symptomatic artery occlusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed the association between qualifying event\u2014the latest ischemic event (transient ischemic attack [TIA] or stroke)\u2014and the incidence of ipsilateral ischemic stroke in patients with symptomatic artery occlusion treated with medical therapy alone in CMOSS (Carotid or Middle Cerebral Artery Occlusion Surgery Study). The incidence of CMOSS primary outcomes, including any stroke or death within 30\u2009days after randomization or ipsilateral ischemic stroke between 30\u2009days and 2\u2009years, between the bypass surgical and medical groups, stratified by qualifying events, was also compared. Of the 165 patients treated with medical therapy alone, 75 had a TIA and 90 had a stroke as their qualifying event. The incidence of ipsilateral ischemic stroke did not significantly differ between patients with a TIA and those with a stroke as their qualifying event (13.3% versus 6.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.17). In multivariate analysis, the qualifying event was not associated with the incidence of ipsilateral ischemic stroke. There were no significant differences in the CMOSS primary outcomes between the surgical and medical groups, regardless of the qualifying event being TIA (10.1% versus 12.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.86) or stroke (6.7% versus 8.9%,\n              <jats:italic>P<\/jats:italic>\n              =0.55).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with symptomatic artery occlusion and hemodynamic insufficiency, the risk of subsequent ipsilateral ischemic stroke does not appear to be lower in patients presenting with a TIA compared with those with a stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01758614.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.034056","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:04:51Z","timestamp":1719497091000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Qualifying Event and Recurrence of Ischemic Stroke in Symptomatic Artery Occlusion: A Post Hoc Analysis of CMOSS"],"prefix":"10.1161","volume":"13","author":[{"given":"Guangdong","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Interventional Neuroradiology Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China"},{"name":"Department of Interventional Radiology The First Affiliated Hospital With Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-0173","authenticated-orcid":false,"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-591X","authenticated-orcid":false,"given":"Renjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-0966","authenticated-orcid":false,"given":"Jichang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huanhu Hospital Tianjin 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Shanxi Medical University and Shanxi Cardiovascular Hospital Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology Strategic Support Force Medical Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Hospital of Lan Zhou University Lan Zhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Qilu Hospital of Shandong University, Jinan, Qilu Hospital of Shandong University Dezhou Hospital Dezhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Medical Center of Chinese People\u2019s Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Maimaitili","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical University Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanjing Drum Tower Hospital, Neurosurgical Institute of Nanjing University Nanjing University Medical School Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 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