{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:43:28Z","timestamp":1793295808000,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) has been reported to be safe and effective at midterm follow\u2010up to treat drug\u2010refractory hypertrophic obstructive cardiomyopathy in a single center. However, data from other centers are lacking. This retrospective cohort study aimed to investigate the efficacy and safety of PIMSRA from another independent center.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              PIMSRA was performed in 76 patients with hypertrophic obstructive cardiomyopathy in our center from April 2020 to June 2023. The primary outcome was the reduction of left ventricular outflow tract gradient after 6\u2009months or more post\u2010PIMSRA. Secondary outcomes were periprocedural major adverse clinical events. Sixty\u2010one patients returned to the hospital for follow\u2010up 6 to 30 (median, 14) months after the procedure. At the last follow\u2010up of the 61 patients, the maximum septal thickness decreased from a median of 23.6 (interquartile range, 20.5\u201326.4) to 19.1 (interquartile range, 16.0\u201322.1) mm (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and the left ventricular outflow tract peak gradient at rest decreased from a median of 70.0 (interquartile range, 29.1\u2013107.5) to 20.0 (interquartile range, 10.8\u201348.8) mm\u2009Hg (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The percentage of patients with symptoms of New York Heart Association functional class III\/IV decreased from 51% to 0%. Of all 76 patients, there was no in\u2010hospital or 30\u2010day death, no right or left branch block, and no permanent pacemaker implantation. Six (8%) patients had pericardial effusion, with 1 experiencing cardiac tamponade and ventricular fibrillation, and 1 (1%) patient developed septal branch aneurysm that was treated with coil occlusion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PIMSRA allows for the reduction in the left ventricular outflow tract gradient and enhances symptomatic improvement, with a limited incidence of adverse events and complications among patients with hypertrophic obstructive cardiomyopathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.034080","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T10:07:17Z","timestamp":1721988437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single\u2010Center, Observational Study"],"prefix":"10.1161","volume":"13","author":[{"given":"Xudong","family":"Xie","sequence":"first","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6374-1303","authenticated-orcid":false,"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]},{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Cui","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-4630","authenticated-orcid":false,"given":"Zhi","family":"Du","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Xing","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]},{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]},{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-9677","authenticated-orcid":false,"given":"Yijiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6754-1432","authenticated-orcid":false,"given":"Xiaogang","family":"Guo","sequence":"additional","affiliation":[{"name":"Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.019"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000938"},{"key":"e_1_3_1_6_2","first-page":"144","article-title":"Aortic subvalvar stenosis: surgical treatment","volume":"108","author":"Brock R","year":"1959","unstructured":"Brock R. 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