{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:24:44Z","timestamp":1791897884212,"version":"4.3.4"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut microbial metabolite of daidzein), and equol\u2010predicting microbial species with cardiometabolic risk markers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a 1\u2010year study of 305 Chinese community\u2010dwelling adults aged \u226518\u2009years, urinary isoflavones, fecal microbiota, blood pressure, blood glucose and lipids, and anthropometric data were measured twice, 1 year apart. Brachial\u2010ankle pulse wave velocity was also measured after 1\u2009year. A linear mixed\u2010effects model was used to analyze repeated measurements. Logistic regression was used to calculate the adjusted odds ratio (aOR) and 95% CI for the associations for arterial stiffness. Each 1 \u03bcg\/g creatinine increase in urinary equol concentrations was associated with 1.47%, 0.96%, and 3.32% decrease in triglycerides, plasma atherogenic index, and metabolic syndrome score, respectively (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), and 0.61% increase in high\u2010density lipoprotein cholesterol (\n              <jats:italic>P<\/jats:italic>\n              =0.025). Urinary equol was also associated with lower risk of arterial stiffness (aOR, 0.28 [95% CI, 0.09\u20130.90];\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.036). We identified 21 bacterial genera whose relative abundance was positively associated with urinary equol (false discovery rate\u2010corrected\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and constructed a microbial species score to reflect the overall equol\u2010predicting capacity. This score (per 1\u2010point increase) was inversely associated with triglycerides (percentage difference=\u22121.48%), plasma atherogenic index (percentage difference=\u22120.85%), and the risk of arterial stiffness (aOR, 0.27 [95% CI, 0.08\u20130.88]; all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our findings suggest that urinary equol and equol\u2010predicting microbial species may improve cardiometabolic risk parameters in Chinese adults.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.034126","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:38:58Z","timestamp":1719499138000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Urinary Equol and Equol\u2010Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8053-256X","authenticated-orcid":false,"given":"Shaoxian","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui China"},{"name":"Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) Ministry of Education of the People\u2019s Republic of China Hefei Anhui China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei Anhui China"},{"name":"Anhui Provincial Key Laboratory of Population Health and Aristogenics, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2447-442X","authenticated-orcid":false,"given":"Honghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5086-4867","authenticated-orcid":false,"given":"Yufeng","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7647-9121","authenticated-orcid":false,"given":"Yamin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5999-9566","authenticated-orcid":false,"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Examination Center The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1664-289X","authenticated-orcid":false,"given":"Hongjuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chronic Noncommunicable Diseases Prevention and Control Lu\u2019an Municipal Center for Disease Control and Prevention Lu\u2019an Anhui 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