{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:11:51Z","timestamp":1790946711846,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">NULL\u2010PLEASE is a simple and accurate clinical scoring system developed in a Western cohort of patients with out\u2010of\u2010hospital cardiac arrest (OHCA). The need for blood test results limits its use in early stages of care. We adapted and validated the NULL\u2010EASE score (without laboratory tests) in an independent, multiethnic Asian cohort of patients with out\u2010of\u2010hospital cardiac arrest.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the Singapore OHCA registry, we included consecutive adult patients with out\u2010of\u2010hospital cardiac arrest who survived to hospital admission between April 2010 to December 2020. In\u2010hospital mortality was the primary outcome. Logistic regression analyses were performed with STATA MP v18. Of 3274 patients (median age 64, interquartile range 54\u201375; 67.9% male) included in the study, 2476 (75.6%) had in\u2010hospital mortality. NULL\u2010EASE score was significantly lower in survivors compared with nonsurvivors (median [inter quartile range] 3 [1\u20134] versus 6 [4\u20137];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and strongly predictive of mortality (area under receiver operating characteristic, 0.81 [95% CI, 0.79\u20130.83]). Patients with a score of \u22653 had higher odds of mortality (adjusted odds ratio, 8.11 [95% CI, 6.57\u201310.00]) when compared with those with lower scores, after adjusting for sex, residential arrest, diabetes, respiratory disease, and stroke. A cutoff value of \u22653 predicted mortality with 92.2% sensitivity, 84.1% positive predictive value, 46.1% specificity, and 65.5% negative predictive value. NULL\u2010EASE score performed better in younger compared with older patients (area under receiver operating characteristic, 0.82 versus 0.77,\n              <jats:italic>P<\/jats:italic>\n              =0.008).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The NULL\u2010EASE score has good discriminative performance (sensitivity and accuracy) in our multiethnic Asian cohort, but the cutoff of \u22653 falls short of the desired level of specificity for therapeutic decision\u2010making.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.034133","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:14:15Z","timestamp":1722424455000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the NULL\u2010EASE Score for Predicting Survival in a Multiethnic Asian Cohort of Out\u2010of\u2010Hospital Cardiac Arrest"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-2357","authenticated-orcid":false,"given":"Shir Lynn","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Pre\u2010hospital and Emergency Research Centre Duke\u2010NUS Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6239-6483","authenticated-orcid":false,"given":"Siew Pang","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Cardiovascular Research Institute National University Heart Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-5273","authenticated-orcid":false,"given":"Nur","family":"Shahidah","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7464-1505","authenticated-orcid":false,"given":"Kai Lee","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-5858","authenticated-orcid":false,"given":"Sean Shao Wei","family":"Lam","sequence":"additional","affiliation":[{"name":"Health Services Research Centre Singapore Health Services Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-8993","authenticated-orcid":false,"given":"Benjamin Sieu\u2010Hon","family":"Leong","sequence":"additional","affiliation":[{"name":"Emergency Department National University Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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