{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:45Z","timestamp":1788876585609,"version":"build-2803163510"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Limited knowledge exists about prophylactic anticoagulation patterns in patients hospitalized for COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We conducted a retrospective cohort study using American Heart Association COVID\u201019 Cardiovascular Disease Registry data from May 2020 to March 2022. We included patients without preexisting indications for or contraindications to anticoagulation, excluding those with missing anticoagulation data. Patients were categorized by the highest anticoagulation dose received. Multilevel logistic regression was used to assess the relationship between anticoagulation use\/dose, patient demographics, clinical presentation, in\u2010hospital course, institutional characteristics, and admission date, accounting for hospital clustering. Among 26\u2009775 patients, 4157 (16%) received no anticoagulation, 15\u2009617 (58%) low\u2010dose, 3071 (11%) intermediate\u2010dose, and 3930 (15%) full\u2010dose anticoagulation. Significant hospital\u2010level variability occurred for any anticoagulation use (range, 0%\u201398%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001) and by dose (full anticoagulation range, 0%\u201385%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001). Controlling for hospital variability, older age, male sex, non\u2010White race, higher body mass index, higher platelets, corticosteroid use, and intensive care unit admission were positively associated with any anticoagulation use. Older age, male sex, higher body mass index, higher platelets, corticosteroid use, intensive care unit admission, mechanical ventilation, and admission before October 2020 were associated with higher anticoagulation dose (full versus low dose). Rates of no anticoagulation significantly increased in both intensive care unit and non\u2010intensive care unit strata over time (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      trend=0.01 and &lt;0.0001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this large real\u2010world analysis, nearly 1 in 6 patients hospitalized for COVID\u201019 received no prophylactic anticoagulation. Patient and disease characteristics associated with thrombotic risk and COVID\u201019 severity correlated with anticoagulation strategy. Importantly, substantial institutional differences emerged, highlighting gaps between clinical practice and guideline recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.034186","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:19:26Z","timestamp":1740986366000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Patterns of Prophylactic Anticoagulation Among Patients Hospitalized for COVID\u201019: An Analysis of the American Heart Association COVID\u201019 Cardiovascular Disease Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-8194","authenticated-orcid":false,"given":"Mathew S.","family":"Lopes","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6270-2589","authenticated-orcid":false,"given":"Hsin\u2010Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Providence Heart Institute","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-393X","authenticated-orcid":false,"given":"Reed J. D.","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Institute for Health Metrics and Evaluation, University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-1925","authenticated-orcid":false,"given":"Sandeep","family":"Das","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-6760","authenticated-orcid":false,"given":"Steven M.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-7261","authenticated-orcid":false,"given":"James A.","family":"de Lemos","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-9146","authenticated-orcid":false,"given":"Gregory A.","family":"Roth","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-8172","authenticated-orcid":false,"given":"Erin A.","family":"Bohula","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7187-6822","authenticated-orcid":false,"given":"Ty J.","family":"Gluckman","sequence":"additional","affiliation":[{"name":"Providence Heart Institute","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04044.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.02.030"},{"key":"e_1_3_2_4_2","volume-title":"Preventing Hospital\u2010Associated Venous Thromboembolism","year":"2024","unstructured":"Preventing Hospital\u2010Associated Venous Thromboembolism. 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