{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:49:37Z","timestamp":1787165377586,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The impact of high\u2010risk coronary artery plaques identified using optical coherence tomography on late luminal narrowing and clinical events remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This multicenter prospective study included 176 patients who underwent percutaneous coronary intervention and serial optical coherence tomography at baseline and 1\u2010year follow\u2010up to investigate nontarget regions with angiographically intermediate stenosis. At 1\u2009year after percutaneous coronary intervention, the coronary artery lumen area decreased significantly from 6.06 (95% CI, 5.60\u20136.53) mm\n                      <jats:sup>2<\/jats:sup>\n                      to 5.88 (95% CI, 5.41\u20136.35) mm\n                      <jats:sup>2<\/jats:sup>\n                      (difference, \u22120.18; 95% CI, \u22120.22 to \u22120.14\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), particularly in thin\u2010cap fibroatheromas, thick\u2010cap fibroatheromas, mixed plaques, and fibrous plaques. The prevalence of fibroatheroma decreased from 38% to 36% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), whereas calcified plaque increased from 31% to 34% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), accompanied by a significant increase in calcium thickness and angle. Diabetes and current smoking habits were independently associated with increasing calcium prevalence. Patients with thin\u2010cap fibroatheroma had a significantly higher 3\u2010year risk of ischemia\u2010driven nontarget vessel revascularization (hazard ratio, 2.42 [95% CI, 1.03\u20135.71];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04), primarily due to revascularization in the imaged region. No significant association was observed between coronary artery calcium prevalence and clinical outcomes within 3\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The coronary artery lumen area significantly decreased over a 1\u2010year interval, particularly in thin\u2010cap fibroatheromas, thick\u2010cap fibroatheromas, mixed plaques, and fibrous plaques. Although thin\u2010cap fibroatheroma prevalence was associated with higher risk of ischemia\u2010driven nontarget vessel revascularization, no significant association was noted between coronary artery calcium prevalence and clinical outcomes within 3\u2009years. The interaction between calcium progression and long\u2010term clinical events necessitates further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\/\">https:\/\/www.umin.ac.jp\/ctr\/<\/jats:ext-link>\n                      ; Unique Identifier: UMIN000031937.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.034458","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:32:53Z","timestamp":1729578773000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Serial Optical Coherence Tomography Assessment of Coronary Atherosclerosis and Long\u2010Term Clinical Outcomes"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-9186","authenticated-orcid":false,"given":"Kyohei","family":"Yamaji","sequence":"first","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Kyoto, Japan"]},{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-327X","authenticated-orcid":false,"given":"Kenji","family":"Kanenawa","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7604-1849","authenticated-orcid":false,"given":"Toru","family":"Morofuji","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, 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