{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:53:53Z","timestamp":1793850833108,"version":"4.6.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The extent to which infarct artery impacts the extent of myocardial injury and outcomes in patients with ST\u2010segment\u2013elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed a pooled analysis using individual patient data from 7 randomized STEMI trials in which myocardial injury within 30\u2009days after primary percutaneous coronary intervention was assessed in 1774 patients by cardiac magnetic resonance (n=1318) or technetium\u201099m sestamibi single\u2010photon emission computed tomography (n=456). Clinical follow\u2010up was performed at a median duration of 351\u2009days (interquartile range, 184\u2013368\u2009days). Infarct size and outcomes were assessed in anterior (infarct vessel=left anterior descending) versus nonanterior (non\u2013left anterior descending) STEMI. Median infarct size (percentage left ventricular myocardial mass) was larger in patients with anterior compared with nonanterior STEMI (19.7% [interquartile range, 9.4%\u201331.7%] versus 12.6% [interquartile range, 5.1%\u201320.5%];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Patients with anterior compared with nonanterior STEMI were at higher risk for 1\u2010year all\u2010cause mortality (6.2% versus 3.6%; adjusted hazard ratio [HR], 1.66 [95% CI, 1.02\u20132.69];\n                      <jats:italic>P<\/jats:italic>\n                      =0.04) and heart failure hospitalization (4.4% versus 2.6%; adjusted HR, 1.96 [95% CI, 1.15\u20133.36];\n                      <jats:italic>P<\/jats:italic>\n                      =0.01). Infarct size was a predictor of subsequent all\u2010cause mortality or heart failure hospitalization in anterior STEMI (adjusted HR per 1% increase, 1.05 [95% CI, 1.03\u20131.07];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), but not in nonanterior STEMI (adjusted HR, 1.02 [95% CI, 0.99\u20131.05];\n                      <jats:italic>P<\/jats:italic>\n                      =0.19). The\n                      <jats:italic>P<\/jats:italic>\n                      value for this interaction was 0.04.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Anterior STEMI was associated with substantially greater myonecrosis after primary percutaneous coronary intervention compared with nonanterior STEMI, contributing in large part to the worse prognosis in patients with anterior infarction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.034748","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T07:18:24Z","timestamp":1725866304000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Relationship Between Infarct Artery, Myocardial Injury, and Outcomes After Primary Percutaneous Coronary Intervention in ST\u2010Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"13","author":[{"given":"Suzanne","family":"de Waha","sequence":"first","affiliation":[{"name":"Heart Center Leipzig at the University of Leipzig Leipzig Germany"},{"name":"University Heart Center L\u00fcbeck and the German Center for Cardiovascular Research L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-0855","authenticated-orcid":false,"given":"Manesh R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig at the University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-910X","authenticated-orcid":false,"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-3291","authenticated-orcid":false,"given":"Christopher B.","family":"Granger","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-1660","authenticated-orcid":false,"given":"Ori","family":"Ben\u2010Yehuda","sequence":"additional","affiliation":[{"name":"University of California San Diego San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lak","family":"Kotinkaduwa","sequence":"additional","affiliation":[{"name":"The Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-4451","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"The Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-246X","authenticated-orcid":false,"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"University Heart Center L\u00fcbeck and the German Center for Cardiovascular Research L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-7178","authenticated-orcid":false,"given":"Harry P.","family":"Selker","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8447","authenticated-orcid":false,"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"The Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-8210","authenticated-orcid":false,"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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