{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:22:14Z","timestamp":1791534134337,"version":"4.3.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The determinants and prognostic value of high\u2010sensitivity cardiac troponin T (hs\u2010cTnT) among patients with a systemic right ventricle are largely unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Ninety\u2010eight patients from the randomized controlled SERVE (Effect of Phosphodiesterase\u20105 Inhibition With Tadalafil on Systemic Right Ventricular Size and Function) trial were included. The correlation between baseline hs\u2010cTnT concentrations and biventricular volumes and function quantified by cardiac magnetic resonance or cardiac multirow detector computed tomography was assessed by adjusted linear regression models. The prognostic value of hs\u2010cTnT was assessed by adjusted Cox proportional hazards models, survival analysis, and concordance statistics. The primary outcome was time to the composite of clinically relevant arrhythmia, hospitalization for heart failure, or all\u2010cause death. Median age was 39 (interquartile range, 32\u201348) years, and 32% were women. Median hs\u2010cTnT concentration was 7 (interquartile range, 4\u201311) ng\/L. Coefficients of determination for the relationship between hs\u2010cTnT concentrations and right ventricular end\u2010systolic volume index and right ventricular ejection fraction (RVEF) were +0.368 (\n              <jats:italic>P<\/jats:italic>\n              =0.046) and \u22120.381 (\n              <jats:italic>P<\/jats:italic>\n              =0.018), respectively. The sex\u2010 and age\u2010adjusted hazard ratio for the primary outcome of hs\u2010cTnT at 2 and 4 times the reference level (5\u2009ng\/L) were 2.89 (95% CI, 1.14\u20137.29) and 4.42 (95% CI, 1.21\u201316.15), respectively. The prognostic performance quantified by the concordance statistics for age\u2010 and sex\u2010adjusted models based on hs\u2010cTnT, right ventricular ejection fraction, and peak oxygen uptake predicted were comparable: 0.71% (95% CI, 0.61\u20130.82), 0.72% (95% CI, 0.59\u20130.84), and 0.71% (95% CI, 0.59\u20130.83), respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Hs\u2010cTnT concentration was significantly correlated with right ventricular ejection fraction and right ventricular end\u2010systolic volume index in patients with a systemic right ventricle. The prognostic accuracy of hs\u2010cTnT was comparable to that of right ventricular ejection fraction and peak oxygen uptake predicted.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03049540.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.034776","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:35:27Z","timestamp":1715337327000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Value and Determinants of High\u2010Sensitivity Cardiac Troponin T in Patients With a Systemic Right Ventricle: Insights From the SERVE Trial"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-0402","authenticated-orcid":false,"given":"Francisco Javier","family":"Ruperti\u2010Repilado","sequence":"first","affiliation":[{"name":"Division of Cardiology University Hospital of Basel Basel Switzerland"},{"name":"Division of Cardiology Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-6637","authenticated-orcid":false,"given":"Philip","family":"Haaf","sequence":"additional","affiliation":[{"name":"Division of Cardiology University Hospital of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-0640","authenticated-orcid":false,"given":"Pedro","family":"Lopez\u2010Ayala","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-6108","authenticated-orcid":false,"given":"Matthias","family":"Greutmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart Center, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8929","authenticated-orcid":false,"given":"Markus","family":"Schwerzmann","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology, Center for Congenital Heart Disease Inselspital, University Hospital Bern Switzerland"},{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-288X","authenticated-orcid":false,"given":"Judith","family":"Bouchardy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Lausanne University Hospital Lausanne Switzerland"},{"name":"Division of Cardiology H\u00f4pitaux Universitaires de Gen\u00e8ve (HUG) Gen\u00e8ve Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-7092","authenticated-orcid":false,"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Vienna, Adult Congenital Heart Disease Program Vienna 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