{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:39Z","timestamp":1790352579538,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Knowledge of local contextual sex differences in the profile and outcome for stroke can improve service delivery. We aimed to determine sex differences in the profile of patients with acute stroke and their associations with in\u2010hospital death in the national hospital database of Chile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We present a retrospective cohort based on the analysis of the 2019 Chilean database of Diagnosis\u2010Related Groups, which represents 70% of the operational expenditure of the public health system. Random\u2010effects multiple logistic regression models were used to determine independent associations of acute stroke (defined by main diagnosis\n                      <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      [\n                      <jats:italic>ICD\u201010<\/jats:italic>\n                      ] codes) and in\u2010hospital death, and reported with odds ratios (ORs) and 95% CIs. Of 1\u2009048\u2009575 hospital discharges, 15\u2009535 were for patients with acute stroke (7074 [45.5%] in women), and 2438 (15.6%) of them died during hospitalization. Differences by sex in sociodemographic and clinical characteristics were identified for stroke and main subtypes. After fully adjusted model, women with ischemic stroke had lower in\u2010hospital death (OR, 0.79 [95% CI, 0.69\u20130.91]) compared with men; other independent predictors included age per year increase (OR, 1.03 [95% CI, 1.03\u20131.04]), chronic kidney disease (OR, 1.47 [95% CI, 1.20\u20131.80]), atrial fibrillation (OR, 1.50 [95% CI, 1.26\u20131.80]), and other risk factors. Conversely, for intracerebral hemorrhage, women had a higher in\u2010hospital mortality rate than men (OR, 1.19 [95% CI, 1.02\u20131.40]); other independent predictors included age per year increase (OR, 1.009 [95% CI, 1.003\u20131.01]), chronic kidney disease (OR, 1.55 [95% CI, 1.23\u20131.97]), oral anticoagulant use (OR, 1.88 [95% CI, 1.37\u20132.58]), and other risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sex differences in characteristics and in\u2010hospital death of hospitalized patients exist for acute stroke in Chile. In\u2010hospital death is higher for acute ischemic stroke in men and higher for intracerebral hemorrhage in women. Future research is needed to better identify contributing factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.035152","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T06:45:21Z","timestamp":1721285121000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Sex Differences in Profile and In\u2010Hospital Death for Acute Stroke in Chile: Data From a Nationwide Hospital Registry"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3219-9056","authenticated-orcid":false,"given":"Marilaura","family":"Nu\u00f1ez","sequence":"first","affiliation":[{"name":"Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7076-1539","authenticated-orcid":false,"given":"Ma.Ignacia","family":"Allende","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4601-8156","authenticated-orcid":false,"given":"Francisca","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]},{"name":"Universitat Ramon Llull","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-0266","authenticated-orcid":false,"given":"Gabriel","family":"Cavada","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Chile","place":["Santiago, Chile"]},{"name":"Facultad de Medicina Universidad Finis Terrae","place":["Santiago, Chile"]},{"name":"Cl\u00ednica Alemana de Santiago","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-4863","authenticated-orcid":false,"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]},{"name":"Faculty of Medicine, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-2255","authenticated-orcid":false,"given":"Paula","family":"Mu\u00f1oz Venturelli","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]},{"name":"Faculty of Medicine, University of New South Wales","place":["Sydney, Australia"]},{"name":"Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010982"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283204"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319915"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032850"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2016.5849"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/219097"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2846"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_1_11_2","unstructured":"Ministerio de Salud Chile Fondo Nacional de Salud . 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