{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:18:04Z","timestamp":1792459084969,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The predictive role of blood pressure variability for all\u2010cause mortality and fatal and nonfatal cardiovascular events has been described in the general population and in patients with diabetes, independently of mean BP. Although systolic blood pressure variability has been proposed as an informative measure for predicting clinical outcomes in patients with chronic kidney disease, its role in kidney transplant recipients is still debatable.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a retrospective, observational, monocentric analysis of all kidney transplant recipients in follow\u2010up at the outpatient Nephrology Clinic of San Martino Hospital from January 1, 2016 to December 31, 2016, who underwent kidney transplantation &gt;12\u2009months. The primary outcome was a fatal or nonfatal cardiovascular event (myocardial infarction, unstable angina, stroke, and hospitalization for heart failure). Visit\u2010to\u2010visit systolic blood pressure variability was expressed as the SD of systolic blood pressure values recorded at baseline and 3 months up to 18\u2009months. Among the 272 patients (mean age, 64\u00b113; 63% men) included in the present analyses, for each increase of 2.7\u2009mm\u2009Hg in systolic blood pressure SD, the risk for events increased 3\u2010fold (hazard ratio [HR], 3.1 [95% CI, 1.19\u20137.88];\n              <jats:italic>P<\/jats:italic>\n              =0.02), and patients in the highest tertile of systolic blood pressure SD showed a 4\u2010fold increased risk (HR, 4.1 [95% CI, 1.34\u201312.43];\n              <jats:italic>P<\/jats:italic>\n              =0.01). This relationship was maintained even after incremental adjustment for time\u2010averaged pulse pressure, age, diabetes, and prior cardiovascular event (HR, 3.2 [95% CI, 1.1\u201310.0];\n              <jats:italic>P<\/jats:italic>\n              =0.04).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Long\u2010term blood pressure variability represents a risk factor for cardiovascular events in kidney transplant recipients, even independently by several confounding factors including blood pressure load.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034108","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:29:52Z","timestamp":1721129392000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Visit\u2010to\u2010Visit Systolic Blood Pressure Variability Independently Predicts Cardiovascular Events in a Kidney Transplant Recipients' Cohort"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-0252","authenticated-orcid":false,"given":"Elisabetta","family":"Bussalino","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]},{"name":"University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-0888","authenticated-orcid":false,"given":"Daniela","family":"Picciotto","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Macci\u00f2","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]},{"name":"University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Parodi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Gandolfo","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-7043","authenticated-orcid":false,"given":"Francesca","family":"Viazzi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]},{"name":"University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002155"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318193"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025513"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw106"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4098"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx760"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13828"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000779"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04660415"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001950"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz053"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13448"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000621"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.6.1410"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab135"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000517358"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022716"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab275"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2023.2181640"}],"container-title":["Journal of the American Heart 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