{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:43:37Z","timestamp":1775177017039,"version":"3.50.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Accumulating evidence suggests that cardiac findings after stroke are an important, yet understudied, manifestation of brain\u2013heart interactions. Our aim was to investigate and compare cardiac findings after different cerebrovascular events (acute ischemic stroke, transient ischemic attack, and hemorrhagic stroke).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      There were 7113 patients screened who were treated between December 2013 and December 2020 at the University Hospital Zurich for ischemic stroke, transient ischemic attack, and hemorrhagic stroke. Seven hundred twenty\u2010one patients without evidence of previous cardiac disease or presumed cardioembolic origin of their cerebrovascular disease and with at least 1 cardiac checkup were included. Clinical reports from the year following disease onset were screened for new cardiac findings, which were categorized as arrhythmia\/electrocardiographic changes, myocardial alterations, valvular abnormalities, and coronary perfusion insufficiency. Differences in proportions of findings among groups were analyzed using the Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test or Fisher exact test. ECG changes were observed in 81.7% (n=474) of patients with ischemic stroke, 71.4% (n=70) of patients with transient ischemic attack, and 55.8% (n=24) of patients with hemorrhagic stroke (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Myocardial alterations occurred often in all 3 groups (60.9% ischemic stroke [n=353], 59.2% transient ischemic attack [n=58], 44.2% hemorrhagic stroke [n=19];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.396).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac findings are frequent in patients with cerebrovascular disease, even without prior cardiac problems or suspected cardiac cause. Similarities, especially between patients with ischemic stroke and transient ischemic attack, were observed. Our data suggest that all patients with acute cerebrovascular events should receive thorough workup searching for cardiac manifestations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.034131","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T12:44:55Z","timestamp":1724762695000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac Findings Following Cerebrovascular Disease"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7017-7377","authenticated-orcid":false,"suffix":"MD","given":"Marco H.","family":"Rohner","sequence":"first","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Inselspital Bern University Hospital","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-7382","authenticated-orcid":false,"given":"Andreas","family":"Luft","sequence":"additional","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]},{"name":"Cereneo, Center for Neurology and Rehabilitation","place":["Vitznau, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-1130","authenticated-orcid":false,"given":"Martin","family":"H\u00e4nsel","sequence":"additional","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-7023","authenticated-orcid":false,"given":"Susanne","family":"Wegener","sequence":"additional","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060020096022"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-011-0161-x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2002.123972"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.6.990"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30336-3"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70266-2"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199402000-00005"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311170"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.11.2059"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.2.1765"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000057"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.058"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01697"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000135711"},{"key":"e_1_3_1_17_2","unstructured":"von Elm E Altman Dg Fau\u2010Egger M Fau\u2010Pocock SJ EM Pocock Sj Fau\u2010G\u00f8tzsche PC G\u00f8tzsche Pc Fau\u2010Vandenbroucke JP Vandenbroucke JP. 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