{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:05:19Z","timestamp":1792209919648,"version":"4.4.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Wild\u2010type transthyretin amyloid (ATTRwt) cardiomyopathy is increasingly recognized in the development of heart failure. The link between cardiac performance, hemodynamics, and mitochondrial function in disease stages of ATTRwt has not previously been studied but may provide new insights into the pathophysiology and clinical performance of the patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study investigated 47 patients diagnosed with ATTRwt at Aarhus University Hospital, Denmark. Patients were stratified according to the disease stages of the National Amyloidosis Centre (NAC) as NAC I with low levels of NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) (NAC I\u2010L, n=14), NAC I with high levels NT\u2010proBNP (NAC I\u2010H, n=20), and NAC II\u2010III (n=13). Exercise testing with simultaneous right heart catheterization was performed in all patients. Endomyocardial biopsies were collected from the patients and the mitochondrial oxidative phosphorylation capacity was assessed. All NAC disease groups, even in the NAC I\u2010L group, a significant abnormal increase in biventricular filling pressures were noted during exercise while the filling pressures was normal or near normal at rest. The inotropic response to exercise was reduced with diminished increase in cardiac output which was significantly more pronounced in the NAC I\u2010H (Diff. \u20102.4, 95% CI (\u22124.2: \u22120.7),\n              <jats:italic>P<\/jats:italic>\n              =0.00) and the NAC II\u2010III group (Diff: \u22123.1 L\/min, 95% CI (\u22125.2: \u22121.1),\n              <jats:italic>P<\/jats:italic>\n              =0.00) compared with the NAC I\u2010L group. The pulmonary artery wedge pressure to cardiac output ratio at peak exercise was significantly different between NAC I\u2010L and NAC II\u2010III (Diff: 1.6\u2009mm\u2009Hg*min\/L, 95% CI (0.01:3.3,\n              <jats:italic>P<\/jats:italic>\n              =0.04)). Patients with ATTRwt had a reduced oxidative phosphorylation capacity which correlated to left ventricular mass but not to cardiac output capacity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">An abnormal restrictive left ventricle and right ventricle response to exercise was demonstrated, even present in patients with early\u2010stage ATTRwt. In more advanced disease stages a progressive impairment of the pressure\u2010flow relationship was noted. The myocyte energetics is deranged but not associated to the contractile reserve or restrictive filling characteristics in ATTRwt.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034213","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:15:20Z","timestamp":1719497720000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Exercise Hemodynamics and Mitochondrial Oxidative Capacity in Disease Stages of Wild\u2010Type Transthyretin Amyloid Cardiomyopathy"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-6789","authenticated-orcid":false,"given":"Bertil","family":"Ladefoged","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-5192","authenticated-orcid":false,"given":"Anders 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Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-3910","authenticated-orcid":false,"given":"Emil","family":"Lichscheidt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-6404","authenticated-orcid":false,"given":"Tor","family":"Clemmensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-9232","authenticated-orcid":false,"given":"Julian David","family":"Gillmore","sequence":"additional","affiliation":[{"name":"The National Amyloidosis Centre, The Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen 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