{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:50:34Z","timestamp":1780393834861,"version":"3.54.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The REHAB\u2010HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial demonstrated that a transitional, tailored, progressive rehabilitation intervention improved physical function, 6\u2010minute walk distance, frailty, quality\u2010of\u2010life, and depression in older patients hospitalized for acute decompensated heart failure. This analysis assessed the impact of atrial fibrillation (AF) on intervention benefits.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Of 349 enrolled patients hospitalized for acute decompensated heart failure (mean age 72.7\u00b18.1\u2009years), 176 (50.4%) had AF. Participants were randomly assigned to 12\u2010week rehabilitation intervention or attention control. The primary outcome was Short Physical Performance Battery score at 3\u2009months. Participants with AF were older (74.4\u00b18.3 versus 70.8\u00b17.5,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and had higher prevalence of heart failure with preserved ejection fraction (58.5% versus 47.4%,\n              <jats:italic>P<\/jats:italic>\n              =0.037). Patients with and without AF had similar improvement in Short Physical Performance Battery score (mean difference between rehabilitation intervention and attention control, 1.5 [95% CI, 0.6\u20132.3] versus 1.5 [95% CI, 0.7\u20132.3];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Those with AF had significant improvement in 6\u2010minute walk distance (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and each of the Short Physical Performance Battery domains: balance, 4\u2010meter walk, and chair rise. Kansas City Cardiomyopathy Questionnaire score significantly improved in patients with AF (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) but not those without AF (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). Interaction\n              <jats:italic>P<\/jats:italic>\n              values for 3\u2010month outcomes by AF status were not significant (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.1). No significant differences were observed in deaths, all\u2010cause rehospitalizations, or heart failure hospitalizations at 6\u2009months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In older, hospitalized patients with acute decompensated heart failure, the presence of AF did not significantly affect the benefit of the rehabilitation intervention on physical function and quality of life. The intervention appears safe and effective regardless of AF status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique Identifier: NCT02196038.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034366","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:28:49Z","timestamp":1726651729000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Atrial Fibrillation Status and Physical Rehabilitation in Older Patients With Acute Decompensated Heart Failure: An Analysis From the REHAB\u2010HF 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