{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:47:34Z","timestamp":1792442854676,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">There have been limited data on the changes in clinical outcomes after the introduction of direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) in real clinical practice. We evaluated the changes in management strategies and long\u2010term outcomes from the warfarin era to the DOAC era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We compared the 2 series of multicenter COMMAND VTE (Contemporary Management and Outcomes in Patients With Venous Thromboembolism) registries in Japan enrolling consecutive patients with acute symptomatic VTE: Registry 1: 3027 patients in the warfarin era (2010\u20132014) and Registry 2: 5197 patients in the DOAC era (2015\u20132020). The prevalence of DOAC use increased more in Registry 2 than in the Registry 1 (Registry 1: 2.6% versus Registry 2: 79%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). The cumulative 5\u2010year incidence of recurrent VTE was significantly lower in Registry 2 than in Registry 1 (10.5% versus 9.5%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.02), and the risk reduction of recurrent VTE in Registry 2 remained significant even after adjusting the confounders (hazard ratio [HR], 0.78 [95% CI, 0.65\u20130.93];\n                      <jats:italic>P<\/jats:italic>\n                      =0.005). The cumulative 5\u2010year incidence of major bleeding was not significantly different between the 2 registries (12.1% versus 13.7%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.26), and the risk of major bleeding between the 2 registries was not significantly different even after adjusting the confounders (HR, 1.04 [95% CI, 0.89\u20131.21];\n                      <jats:italic>P<\/jats:italic>\n                      =0.63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Along with the shift from warfarin to DOACs, there was a lower risk of recurrent VTE in the DOAC era than in the warfarin era, whereas there was no apparent change in the risk of major bleeding, which might still be an unmet need even in the DOAC era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.034412","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:36:49Z","timestamp":1722411409000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Temporal Changes in Long\u2010Term Outcomes of Venous Thromboembolism From the Warfarin Era to the Direct Oral Anticoagulant Era"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-5975","authenticated-orcid":false,"given":"Kazuhisa","family":"Kaneda","sequence":"first","affiliation":[{"name":"Kyoto University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-1321","authenticated-orcid":false,"given":"Yugo","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Kyoto University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Hyogo College of Medicine","place":["Nishinomiya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7622-8494","authenticated-orcid":false,"given":"Ryuki","family":"Chatani","sequence":"additional","affiliation":[{"name":"Kurashiki Central Hospital","place":["Kurashiki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-8540","authenticated-orcid":false,"given":"Yuji","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Amagasaki General Medical Center","place":["Amagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-3736","authenticated-orcid":false,"given":"Nobutaka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Toho University Ohashi Medical Center","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Osaka Red Cross Hospital","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-8038","authenticated-orcid":false,"given":"Satoshi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitae","family":"Kim","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, 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