{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:05:22Z","timestamp":1789722322562,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure exhibits sex\u2010based differences in prevalence, clinical characteristics, and outcomes. However, these differences may have an interaction with age. This study investigates these disparities in Asian patients with acute heart failure according to age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We pooled data from the KorHF (Korea Heart Failure) and the KorAHF (Korean Acute Heart Failure) registries including 3200 patients between 2005 and 2009 and 5625 patients between 2011 and\u00a02014, respectively, hospitalized for acute heart failure in Korea. Patients were categorized by their age into 2 groups: those with age \u226570\u2009years and those with age &lt;70\u2009years. The primary endpoint was in\u2010hospital and postdischarge outcomes according to sex, stratified by age. Of 8825 patients, 45.7% had an age &lt;70\u2009years, and 54.3% had an age \u226570\u2009years. Women were older on average in both groups. Differences in baseline characteristics were more apparent in the older group, with women having a higher prevalence of hypertension and valvular heart disease, whereas more men had chronic kidney disease, previous myocardial infarction, chronic obstructive pulmonary disease, and strokes. Both in\u2010hospital and postdischarge mortalities showed differences only in the older group, with men dying more (5.08% versus 7.41%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; 17.95% versus 22.20%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 respectively). This pattern persisted to adjusted analyses, which revealed that men have a 54% (odds ratio, 1.54 [95% CI, 1.17\u20132.04]) and 30% (hazard ratio, 1.30 [95% CI, 1.13\u20131.51]) increased in\u2010hospital and 1\u2010year mortality, respectively, compared with women.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients hospitalized with acute heart failure, male sex is an independent predictor of mortality in older patients but not younger patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034419","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T10:07:08Z","timestamp":1721988428000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Differential Effect of Sex on Mortality According to Age in Heart Failure"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1751-4111","authenticated-orcid":false,"given":"Yoonpyo","family":"Lee","sequence":"first","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seongnam, Republic of Korea"]},{"name":"Monash University","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-655X","authenticated-orcid":false,"given":"Minjae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-2189","authenticated-orcid":false,"given":"Dong\u2010Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-1490","authenticated-orcid":false,"given":"Jin Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.36628\/ijhf.2020.0004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.12.025"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060792"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz835"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.01.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-023-00593-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.053"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022404"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12815"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018574"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027551"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009806"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.91"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2011.41.7.363"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2016.0419"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.03.011"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.618398"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494808100274"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1059840519840805"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00059814"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-022-01183-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2020.120"},{"key":"e_1_3_2_24_2","article-title":"Sex differences for heart failure patients with preserved and reduced systolic function: data from the American Heart Association get with the guidelines\u2010heart failure","volume":"124","author":"Eileen Hsich MVG\u2010S","year":"2018","unstructured":"Eileen Hsich MVG\u2010S, Hernandez A, Peterson ED, Schwamm LH, Bhatt DL. Sex differences for heart failure patients with preserved and reduced systolic function: data from the American Heart Association get with the guidelines\u2010heart failure. 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