{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:03:33Z","timestamp":1781651013256,"version":"3.54.5"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Multiple target\u2010organ damages (TODs) in the same patient are common and further increase the risk of cardiovascular disease. However, the relationship between ambulatory central systolic blood pressure (SBP) and multiple TODs has yet to be explored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              MobilO\u2010Graph PWA was used to monitor the participants' ambulatory blood pressure, and the presence of left ventricular hypertrophy, carotid hypertrophy, and kidney injury were used to define TOD. Logistic regression analyses and receiver operating characteristic analyses were used to explore the correlation between SBP and TOD. Overall, 2018 nondialysis patients with chronic kidney disease were included and 580 (28.74%) had multiple TODs. Twenty\u2010four\u2010hour central SBP with c2 calibration exhibited a stronger correlation with the increasing number of TOD compared with 24\u2010hour brachial SBP in ordinal logistic regression analyses. In the multivariable analyses with the presence of multiple TODs, the odds ratios were 1.786 (95% CI, 1.474\u20132.165;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for 24\u2010hour brachial SBP and 1.949 (95% CI, 1.605\u20132.366;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for 24\u2010hour central SBP with c2 calibration. The receiver operating characteristic analyses also showed that 24\u2010hour central SBP with c2 calibration had higher discrimination than 24\u2010hour brachial SBP regarding multiple TODs (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In addition, using 130\/135\u2009mm\u2009Hg as the threshold for 24\u2010hour brachial SBP\/central SBP with c2 calibration to cross\u2010classify, the prevalence of multiple TODs was greater in cases of concordant hypertension compared with cases of isolated brachial hypertension and concordant normotension, with no difference between the latter 2 conditions.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Twenty\u2010four\u2010hour central SBP with c2 calibration was more associated with the presence of multiple TODs compared with 24\u2010hour brachial SBP and was helpful in risk classification of multiple TODs among nondialysis patients with chronic kidney disease.<\/jats:p>\n          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