{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:38:24Z","timestamp":1790735904683,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We evaluated how elevated blood pressure in children exposed to preeclampsia (PE) impacted on their cardiac structure and function, as well as relations with maternal, gestational, and perinatal factors and child body size and composition.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 182 PE (46 early\u2010onset preeclampsia) and 85 unexposed (non\u2010PE) children were examined in the FINNCARE study 8 to 12\u2009years after the index pregnancy with echocardiography; office, central, and 24\u2010hour ambulatory blood pressures; and body anthropometrics and composition. PE children had lower right ventricular basal sphericity index (mean difference, \u22120.26 95% CI, \u22120.39 to \u22120.12) and lower mitral lateral\n              <jats:italic>E<\/jats:italic>\n              \u2032\u2010wave peak velocity (\u22121.4\u2009cm\/s [95% CI, \u22122.1 to \u22120.6]), as well as higher\n              <jats:italic>E<\/jats:italic>\n              to\n              <jats:italic>E<\/jats:italic>\n              \u2032 ratio (0.40 [95% CI, 0.15\u20130.65]) and indexed tricuspid annular plane systolic excursion (0.03 [95% CI, 0.01\u20130.05]) compared with non\u2010PE children. These differences were accentuated in early\u2010onset PE children. Left ventricular mass (LVM) or left atrial volume were not different between PE and non\u2010PE children. Lean body mass, body fat percentage, and 24\u2010hour systolic blood pressure were independent predictors of LVM. Lean body mass and body fat percentage were independent predictors of left atrial volume. No significant associations between LVM or left atrial volume and maternal, gestational, or perinatal parameters were found.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Preadolescent PE children display a more globular\u2010shaped right ventricle with higher longitudinal systolic displacement as well as mildly altered diastolic indices, with the alterations being pronounced in early\u2010onset preeclampsia. Lean body mass and adiposity are independently related with LVM and left atrial volume, and systolic blood pressure with LVM in both PE and non\u2010PE children. These unfavorable associations indicate remodeling of cardiac structure in young children also reflected in mild functional changes in PE children.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; unique identifier: NCT04676295.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034494","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:30:08Z","timestamp":1721129408000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac Structure and Function in 8\u2010 to 12\u2010Year\u2010Old Children Following In\u2010Utero Exposure to Preeclampsia (FINNCARE Study)"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-3748","authenticated-orcid":false,"given":"Michelle","family":"Renlund\u2010Vikstr\u00f6m","sequence":"first","affiliation":[{"name":"University of Helsinki and Helsinki University Hospital","place":["Helsinki, Finland"]},{"name":"Minerva Foundation Institute for Medical Research","place":["Helsinki, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-0936","authenticated-orcid":false,"given":"Tiina J.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"University of Helsinki and Helsinki University Hospital","place":["Helsinki, Finland"]},{"name":"University of Helsinki","place":["Helsinki, 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