{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:01:26Z","timestamp":1790312486228,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hypertension is the leading risk factor for cardiovascular disease worldwide. Patients with blood pressure (BP) response to dietary sodium reduction are referred to as \u201csalt sensitive.\u201d Salt sensitivity (SS) might be due to differences in sodium storage capacity and the erythrocyte SS examines this capacity of the red blood cells. This study aimed to test the effect of a self\u2010performed sodium reduced diet on BP in patients with essential hypertension and examine whether erythrocyte SS predicts SS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Seventy\u2010two patients with hypertension were included and randomized 2:1 to either sodium reduction or a control group for 4\u2009weeks. Blood samples, 24\u2010hour BP measurement, and 24\u2010hour urine collection were performed before and after. The intervention group received advice on how to lower sodium intake. Urinary sodium excretion decreased 66\u2009mmol (95% CI, \u221296 to \u221237\u2009mmol) in the intervention group compared with the control group. Systolic 24\u2010hour BP decreased 9\u2009mm\u2009Hg after low\u2010sodium diet compared with the control group (95% CI, \u221213 to \u22124\u2009mm\u2009Hg). Similarly, the difference in reduction in diastolic BP between the groups was 5\u2009mm\u2009Hg (95% CI, \u22128 to \u22121\u2009mm\u2009Hg). We found no correlation between erythrocyte SS at baseline and decrease in 24\u2010hour BP, neither systolic nor diastolic (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.66 and\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009=\u20090.84).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Self\u2010performed sodium reduction was feasible and led to decrease in 24\u2010hour BP of 9\/5\u2009mm\u2009Hg compared with a control group. The erythrocyte SS did not correlate to the change in BP after lowering sodium intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT05165823.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.034632","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:46:48Z","timestamp":1717663608000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Self\u2010Performed Dietary Sodium Reduction and Blood Pressure in Patients With Essential Hypertension: A Randomized Clinical Trial"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2241-5791","authenticated-orcid":false,"given":"Camilla Lundgreen","family":"Duus","sequence":"first","affiliation":[{"name":"G\u00f8dstrup Hospital","place":["Herning, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5410-1088","authenticated-orcid":false,"given":"Steffen Flindt","family":"Nielsen","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital","place":["Herning, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-5068","authenticated-orcid":false,"given":"Bodil Gade","family":"Hornstrup","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital","place":["Herning, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-5814","authenticated-orcid":false,"given":"Frank Holden","family":"Mose","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital","place":["Herning, Denmark"]},{"name":"Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-1277","authenticated-orcid":false,"given":"Jesper N\u00f8rgaard","family":"Bech","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital","place":["Herning, Denmark"]},{"name":"Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200401000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)11403-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)60655-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200101043440101"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2301036"},{"key":"e_1_3_2_8_2","unstructured":"Rasmussen LBL Dahl A. 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