{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:54:47Z","timestamp":1790369687521,"version":"4.1.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Emerging evidence suggests a central role for inflammation in cardiac conduction disorder (CCD). It is unknown whether habitual physical activity could modulate the inflammation\u2010associated risks of incident CCD in the general population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This population\u2010based cohort was derived from the China Kailuan study, including a total of 97\u2009192 participants without prior CCD. The end points included incident CCD and its subcategories (atrioventricular block and bundle\u2010branch block). Systemic inflammation was indicated by the monocyte\u2010to\u2010lymphocyte ratio (MLR). Over a median 10.91\u2010year follow\u2010up, 3747 cases of CCD occurred, with 1062 cases of atrioventricular block and 2697 cases of bundle\u2010branch block. An overall linear dose\u2010dependent relationship was observed between MLR and each study end point (all\n              <jats:italic>P<\/jats:italic>\n              \u2010nonlinearity\u22650.05). Both higher MLR and physical inactivity were significantly associated with higher risks of conduction block. The MLR\u2010associated risks of developing study end points were higher in the physically inactive individuals than in those being physically active, with significant interactions between MLR levels and physical activity for developing CCD (\n              <jats:italic>P<\/jats:italic>\n              \u2010interaction=0.07) and bundle\u2010branch block (\n              <jats:italic>P<\/jats:italic>\n              \u2010interaction&lt;0.05) found. Compared with those in MLR quartile 2 and being physically active, those in the highest MLR quartile and being physically inactive had significantly higher risks for all study end points (1.42 [95% CI, 1.24\u20131.63], 1.62 [95% CI, 1.25\u20132.10], and 1.33 [95% CI, 1.13\u20131.56], respectively, for incident CCD, atrioventricular block, and bundle\u2010branch block).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">MLR should be a biomarker for the risk assessment of incident CCD. Adherence to habitual physical activity is favorable for reducing the MLR\u2010associated risks of CCD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.034754","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T14:44:01Z","timestamp":1724078641000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Physical Activity Modifies the Risk of Incident Cardiac Conduction Disorders Upon Inflammation: A Population\u2010Based Cohort Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5130-4815","authenticated-orcid":false,"given":"Haiyan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School North China University of Science and Technology Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-6557","authenticated-orcid":false,"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second Affiliated Hospital of Shantou University Medical College Shantou Guangdong China"},{"name":"Centre for Precision Health Edith Cowan University School of Medical and Health Sciences Joondalup WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-7471","authenticated-orcid":false,"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-9063","authenticated-orcid":false,"given":"Chenrui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-9709","authenticated-orcid":false,"given":"Yulong","family":"Lan","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University School of Medical and Health Sciences Joondalup WA USA"},{"name":"Department of Cardiology Second Affiliated Hospital of Shantou University Medical College Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0885-3779","authenticated-orcid":false,"given":"Hongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-6022","authenticated-orcid":false,"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4176"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13814788.2019.1639667"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02105-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2016.11.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154618"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.22.2494"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs291"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.04.040"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-018-0407-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz924"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2004.19.3.171"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.2502"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00609.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.07.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027247"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2729"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02770-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01987-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9852507"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00520-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac799"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.963694"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0469"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.103879"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02985-x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/a6bvty"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCUALTIONAHA.108.189742"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.260828"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042525"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.08.012"},{"key":"e_1_3_2_35_2","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut\u2010off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou BF","year":"2002","unstructured":"Zhou BF. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut\u2010off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15:83\u201396.","journal-title":"Biomed Environ Sci"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.144832"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.606"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080504"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2848"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000129508.82783.94"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.01.016"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2003"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.03.002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1349-6"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00897-1"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.03.016"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814378"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12844"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00823-5"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab024"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13344"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.09.007"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.61"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1041591"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212341"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12177"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02076-z"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4758"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029241"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.034754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T09:29:14Z","timestamp":1732786154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.034754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":61,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,8,20]]}},"alternative-id":["10.1161\/JAHA.124.034754"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.034754","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e034754"}}